Final Report Summary - DOSE (Dosage sensitive genes in evolution and disease)
In the course of this project we were successful in identifying these evolutionary hallmarks of dosage-sensitive genes and showed that they are indeed often associated with human disease when there is a mutation that changes the number of copies. This is a powerful and efficient approach to quickly identify candidate human disease genes which can then be investigated further. In the course of this project we also developed new methods for the analysis of genome evolution which will be useful for many other projects.