Objetivo
CosmoPHOS-nano is a multidisciplinary, translational and business-oriented project, aiming to accomplish the following objectives:
1) develop the CosmoPHOS system, which is a novel theranostic (diagnostic & therapeutic) nanotechnology-enabled portable combination system enabling endovascular in vivo near-infrared fluorescence molecular imaging, endovascular near-infrared targeted photodynamic therapy, real-time & follow-up therapy monitoring of atherosclerotic coronary artery disease (CAD),
2) nonclinically evaluate this system,
3) clinically validate the system after regulatory approval, &
4) reduce in the long-term CAD deaths and morbidity by up to 40%, resulting in a significant decrease of the European and global healthcare costs for CAD, increasing the income of the European healthcare industry from CAD market which is the global largest. The CosmoPHOS-nano consortium has a five year history of successful collaboration between the industrial and academic partners, and its funding would underpin a team devoted to delivering a novel powerful & affordable healthcare solution against the leading cause of death, without the need for heavy and expensive medical equipment.
The CosmoPHOS system consists of two interacting components:
a) targeted theranostic near-infrared photoactivatable biocompatible nanomedicines, and
b) medical devices.
After systemic administration, the nanomedicines targeted accumulate in coronary atherosclerotic plaques, followed by endocoronary photoactivation and detection by the medical devices, enabling molecular imaging, targeted therapy, real-time & follow-up therapy monitoring of CAD. Preliminary in vitro & in vivo successful experimental results, as well as parts of the CosmoPHOS system are already available from the prior five year collaboration.
The project plan includes: A) nonclinical R&D (30 months); B) nonclinical validation & regulatory approval (18 months); C) first-in-man phase-I clinical trial in 20 CAD patients (12 months).
Ámbito científico
Convocatoria de propuestas
FP7-NMP-2012-LARGE-6
Consulte otros proyectos de esta convocatoria
Régimen de financiación
CP-IP - Large-scale integrating projectCoordinador
70211 KUOPIO
Finlandia
Ver en el mapa
Participantes (18)
55133 THESSALONIKI
Ver en el mapa
14195 Berlin
Ver en el mapa
28049 Madrid
Ver en el mapa
80333 Muenchen
Ver en el mapa
KT9 2NY Chessington
Ver en el mapa
1165 Kobenhavn
Ver en el mapa
101-0054 TOKYO CHIYODA-KU
Ver en el mapa
1085 Budapest
Ver en el mapa
1122 Budapest
Ver en el mapa
3584 CS Utrecht
Ver en el mapa
3000 Leuven
Ver en el mapa
61051 POZNAN
Ver en el mapa
20139 Milano
Ver en el mapa
6525 XZ Nijmegen
Ver en el mapa
70803 Baton Rouge
Ver en el mapa
11635 Athina
Ver en el mapa
LN1 1XW Lincoln
Ver en el mapa
70029 Kys
Ver en el mapa