Objective
The current status of rapidly increasing demand for organ and tissue transplantation in Europe and world wide has promoted tissue engineering as a promising alternative, in particular the use of stem cells. Human embryonic stem cells (hESC) have the advantage of differentiating to all cell types in the body and high proliferation capabilities. Considering their ability to organize into complex multi-cell type structures during embryonic-like differentiation, hESC can potentially provide a source of cells for tissue engineering applications and meet the growing demand for viable human tissue structures in therapeutic clinical application. The aim of this proposed program is to develop a new approach for the use of human embryonic stem cells (hESC) in engineering tissue substitutes, using three-dimensional cultures on biodegradable polymeric scaffolds.
Our experimental strategy will comprise of:
i) Three-dimensional culture of differentiating hESC on polymer scaffolds and in vitro tissue vascularization.
ii) Engineering complex vascularized tissue substitutes and their implantation in immune deficient animals to study integration and vascularization in vivo.
We intend to focus on three-dimensional multi cell-type interactions and organization, and to study the key factors in the vascularization process. Full comprehension and control of hESC differentiation and 3D organization could pave the way to develop new tools for engineering human tissues from hESC for tissue repair and various transplantations. This can also provide unique culture systems for studying human embryonic cellular interactions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology tissue engineering
- natural sciences chemical sciences polymer sciences
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine transplantation
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
HAIFA
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.