Final Activity Report Summary - BRONTE (BRONTE: Biological processes Redescriptions by Ontology Expressions)
The BRONTE project performed basic research in the analysis and meta-analysis of time-course high throughput gene expression measurement experiments as produced by micro-array technology. The key driver behind the project has been the desire to provide a more temporally localised view of the biological processes in which the measured genes may be involved.
The most important result of the BRONTE project has been to devise, apply and refine a number of algorithms based on kernel methods that improve on regular approaches for functional enrichment studies of gene expression experiments. The newly devised methods have been extended in order to make them applicable in the context of the analysis of time-course experiments. Finally, the newly devised methods have been tested against simpler ones based on different measures using a set of metrics derived from literature and an entropy based metric constructed for the project specific goals; these tests have proved that our methods are competitive while providing more informative results.
The most important result of the BRONTE project has been to devise, apply and refine a number of algorithms based on kernel methods that improve on regular approaches for functional enrichment studies of gene expression experiments. The newly devised methods have been extended in order to make them applicable in the context of the analysis of time-course experiments. Finally, the newly devised methods have been tested against simpler ones based on different measures using a set of metrics derived from literature and an entropy based metric constructed for the project specific goals; these tests have proved that our methods are competitive while providing more informative results.