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BlueGenics – From gene to bioactive product: Exploiting marine genomics for an innovative and sustainable European blue biotechnology industry

Objective

Marine organisms, in particular sponges and their associated microorganisms, are an inexhaustible source of novel bioactive (lead) compounds for biomedical application. Industrial exploitation of this natural resource using traditional approaches is, however, hampered, with a few exceptions, by unsolvable supply problems - despite of numerous efforts in the past. Therefore, there is, very likely, only one way: to start from the genes encoding the bioproducts, or their biosynthetic pathways, to sustainably obtain the active molecules in sufficient amounts. The aim of the presented industry-driven integrating project is to combine the knowledge in marine genomics, chemogenetics and advanced chemistry to produce recombinantly prepared novel secondary metabolite (lead) compounds and analogous from them, as well as pharmacologically active peptides, and to bring them up to the pre-clinical, and hopefully also to the clinical studies. This ambitious approach is based on breakthrough discoveries and the results of previous successful EU projects of members of the applying consortium, including European leaders (or worldwide leaders) in marine (sponge) genomics, metagenomics (polyketide synthase clusters), combinatorial biosynthesis and marine natural product chemistry/structure elucidation. This multidisciplinary project, driven by high-tech genomics-based SMEs with dedicated interest in bringing marine-biotechnology-derived products to the market, will also involve the discovery and sustainable production of bioactive molecules from hitherto unexploited extreme environments, such as hydrothermal vents and deep-sea sources, and the expression/scale-up of unique enzymes/proteins of biomedical and biotechnological interest. The molecular-biology-based strategies developed in this project for a sustainable exploitation of aquatic molecular biodiversity will further strengthen the international position and effectiveness of European (SME-based) blue biotechnology industry.

Call for proposal

FP7-KBBE-2012-6-singlestage
See other projects for this call

Funding Scheme

CP-TP - Collaborative Project targeted to a special group (such as SMEs)

Coordinator

UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Address
Langenbeckstrasse 1
55131 Mainz
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 181 039
Administrative Contact
Silvia Tschauder (Dr.)

Participants (17)

ManRos Therapeutics
France
EU contribution
€ 504 780
Address
Rue Bir Hakeim 16
29680 Roscoff
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Laurent Meijer (Dr.)
BIOALVO S.A.

Participation ended

Portugal
Address
Edifício Icat, Campus Da Fcul, Campo Grande
1749-016 Lisbon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patricia Calado (Dr.)
NANOTECMARIN GMBH
Germany
EU contribution
€ 521 284
Address
Muhlstrasse 19
55218 Ingelheim Am Rhein
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Heinz C. Schröder (Prof.)
SAEBYLI EHF
Iceland
EU contribution
€ 170 702
Address
Budarstigur 23
820 Eyrarbakki
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Asgeir Gudnason (Mr.)
PROKAZYME EHF
Iceland
EU contribution
€ 80 800
Address
Vinlandsleio 14
113 Reykjavik
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jakob Kristjansson (Dr.)
FIDELTA D.O.O. ZA ISTRAZIVANJE I RAZVOJ
Croatia
EU contribution
€ 520 640
Address
Prilaz Baruna Filipovca 29
10000 Zagreb
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Lidija Herceg Harjacek (Dr.)
BIOTREND-INOVACAO E ENGENHARIA EM BIOTECNOLOGIA SA
Portugal
EU contribution
€ 295 020
Address
Biocant Park Nucleo 4 Lote 2
3060-197 Cantanhede
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Bruno Sommer Ferreira (Dr.)
MATIS OHF
Iceland
EU contribution
€ 346 850
Address
Vinlandsleid 12
113 Reykjavik
Activity type
Research Organisations
Administrative Contact
Anna Kristin Danielsdottir (Dr.)
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italy
EU contribution
€ 588 610
Address
Corso Umberto I, 40
80138 Napoli
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alfonso Mangoni (Prof.)
UNIVERSITY OF EAST ANGLIA

Participation ended

United Kingdom
Address
Earlham Road
NR4 7TJ Norwich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Chris Killen (Dr.)
RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN

Participation ended

Germany
Address
Regina Pacis Weg 3
53113 Bonn
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Daniela Hasenpusch (Ms.)
MUSEUM NATIONAL D'HISTOIRE NATURELLE
France
EU contribution
€ 323 532
Address
Rue Cuvier 57
75005 Paris
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Vanessa Demanoff (Ms.)
UPPSALA UNIVERSITET
Sweden
EU contribution
€ 311 240
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gunilla Eriksson (Ms.)
RUDER BOSKOVIC INSTITUTE
Croatia
EU contribution
€ 182 442
Address
Bijenicka Cesta 54
10000 Zagreb
Activity type
Research Organisations
Administrative Contact
Renato Batel (Dr.)
National Research Center for Geoanalysis
China
EU contribution
€ 156 600
Address
Baiwanzhuang 26
100037 Beijing
Activity type
Research Organisations
Administrative Contact
Xiaohong Wang (Prof.)
THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
United Kingdom
EU contribution
€ 390 090
Address
North Street 66 College Gate
KY16 9AJ St Andrews
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Trish Starrs (Mrs.)
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 426 240
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Susanne Jäger (Ms.)