Objective Marine organisms, in particular sponges and their associated microorganisms, are an inexhaustible source of novel bioactive (lead) compounds for biomedical application. Industrial exploitation of this natural resource using traditional approaches is, however, hampered, with a few exceptions, by unsolvable supply problems - despite of numerous efforts in the past. Therefore, there is, very likely, only one way: to start from the genes encoding the bioproducts, or their biosynthetic pathways, to sustainably obtain the active molecules in sufficient amounts. The aim of the presented industry-driven integrating project is to combine the knowledge in marine genomics, chemogenetics and advanced chemistry to produce recombinantly prepared novel secondary metabolite (lead) compounds and analogous from them, as well as pharmacologically active peptides, and to bring them up to the pre-clinical, and hopefully also to the clinical studies. This ambitious approach is based on breakthrough discoveries and the results of previous successful EU projects of members of the applying consortium, including European leaders (or worldwide leaders) in marine (sponge) genomics, metagenomics (polyketide synthase clusters), combinatorial biosynthesis and marine natural product chemistry/structure elucidation. This multidisciplinary project, driven by high-tech genomics-based SMEs with dedicated interest in bringing marine-biotechnology-derived products to the market, will also involve the discovery and sustainable production of bioactive molecules from hitherto unexploited extreme environments, such as hydrothermal vents and deep-sea sources, and the expression/scale-up of unique enzymes/proteins of biomedical and biotechnological interest. The molecular-biology-based strategies developed in this project for a sustainable exploitation of aquatic molecular biodiversity will further strengthen the international position and effectiveness of European (SME-based) blue biotechnology industry. Fields of science natural sciencesbiological sciencesgeneticsnatural sciencesbiological sciencesecologyecosystemssocial scienceseconomics and businesseconomicssustainable economynatural sciencesbiological sciencesmicrobiologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programme(s) FP7-KBBE - Specific Programme "Cooperation": Food, Agriculture and Biotechnology Topic(s) KBBE.2012.3.2-01 - Innovative marine biodiscovery pipelines for novel industrial products Call for proposal FP7-KBBE-2012-6-singlestage See other projects for this call Funding Scheme CP-TP - Collaborative Project targeted to a special group (such as SMEs) Coordinator UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ Address Langenbeckstrasse 1 55131 Mainz Germany See on map Region Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Silvia Tschauder (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (17) Sort alphabetically Sort by EU Contribution Expand all Collapse all ManRos Therapeutics France EU contribution € 504 780,00 Address Rue bir hakeim 16 29680 Roscoff See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Laurent Meijer (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data BIOALVO S.A. Participation ended Portugal EU contribution € 0,00 Address Edifício icat, campus da fcul, campo grande 1749-016 Lisbon See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Patricia Calado (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data NANOTECMARIN GMBH Germany EU contribution € 521 284,00 Address Muhlstrasse 19 55218 Ingelheim am rhein See on map Region Rheinland-Pfalz Rheinhessen-Pfalz Mainz-Bingen Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Heinz C. Schröder (Prof.) Links Contact the organisation Opens in new window Other funding No data SAEBYLI EHF Iceland EU contribution € 170 702,00 Address Budarstigur 23 820 Eyrarbakki See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Asgeir Gudnason (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data PROKAZYME EHF Iceland EU contribution € 80 800,00 Address Vinlandsleio 14 113 Reykjavik See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jakob Kristjansson (Dr.) Links Contact the organisation Opens in new window Other funding No data FIDELTA D.O.O. ZA ISTRAZIVANJE I RAZVOJ Croatia EU contribution € 520 640,00 Address Prilaz baruna filipovca 29 10000 Zagreb See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Lidija Herceg Harjacek (Dr.) Links Contact the organisation Opens in new window Other funding No data BIOTREND-INOVACAO E ENGENHARIA EM BIOTECNOLOGIA SA Portugal EU contribution € 295 020,00 Address Biocant park nucleo 4 lote 2 3060-197 Cantanhede See on map Region Continente Centro (PT) Região de Coimbra Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Bruno Sommer Ferreira (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data MATIS OHF Iceland EU contribution € 346 850,00 Address Vinlandsleid 12 113 Reykjavik See on map Region Ísland Ísland Höfuðborgarsvæði Activity type Research Organisations Administrative Contact Anna Kristin Danielsdottir (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II Italy EU contribution € 588 610,00 Address Corso umberto i, 40 80138 Napoli See on map Region Sud Campania Napoli Activity type Higher or Secondary Education Establishments Administrative Contact Alfonso Mangoni (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITY OF EAST ANGLIA Participation ended United Kingdom EU contribution € 0,00 Address Earlham road NR4 7TJ Norwich See on map Region East of England East Anglia Norwich and East Norfolk Activity type Higher or Secondary Education Establishments Administrative Contact Chris Killen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN Participation ended Germany EU contribution € 0,00 Address Regina pacis weg 3 53113 Bonn See on map Region Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Daniela Hasenpusch (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data MUSEUM NATIONAL D'HISTOIRE NATURELLE France EU contribution € 323 532,00 Address Rue cuvier 57 75005 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Higher or Secondary Education Establishments Administrative Contact Vanessa Demanoff (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UPPSALA UNIVERSITET Sweden EU contribution € 311 240,00 Address Von kraemers alle 4 751 05 Uppsala See on map Region Östra Sverige Östra Mellansverige Uppsala län Activity type Higher or Secondary Education Establishments Administrative Contact Gunilla Eriksson (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data RUDER BOSKOVIC INSTITUTE Croatia EU contribution € 182 442,00 Address Bijenicka cesta 54 10000 Zagreb See on map Region Hrvatska Grad Zagreb Grad Zagreb Activity type Research Organisations Administrative Contact Renato Batel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data National Research Center for Geoanalysis China EU contribution € 156 600,00 Address Baiwanzhuang 26 100037 Beijing See on map Activity type Research Organisations Administrative Contact Xiaohong Wang (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS United Kingdom EU contribution € 390 090,00 Address North street 66 college gate KY16 9AJ St andrews See on map Region Scotland Eastern Scotland Clackmannanshire and Fife Activity type Higher or Secondary Education Establishments Administrative Contact Trish Starrs (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland EU contribution € 426 240,00 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Susanne Jäger (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
