Objective Protein kinases are involved in the control of a large number of cellular processes and play a central role in human physiology. More than 500 genes encoding protein kinases have been identified in the human genome, and it is estimated that about 30% of all human proteins may be phosphorylated by kinases. Deficiency in kinase activity has implications in cancer, central nervous system disorders, autoimmune diseases and immunosuppression, diabetes, osteoporosis and various metabolic disorders. Small-molecule kinase inhibitors have therefore moved into the focus of the pharmaceutical industry as a new class of drugs, which is expected to produce new and more efficient treatments and grow significantly within the coming decade.The proposed project brings together the unique and proprietary technologies of three SMEs and the expertise of academic research partners to create a new platform for lead compound discovery with a focus on protein kinases. Three kinases will be targeted for the development of inhibitory compounds. The academic partners will contribute a modern high throughput platform for protein expression and crystallisation (Israel Structural Proteomics Centre), and expertise in the biochemistry and biology of the targeted kinases combined with the principles of the use of bioisosterism in synthesis of novel chemical compounds (University of Turin). The applied principles and technologies will provide new IP opportunities for the partner SMEs in the otherwise crowded kinase inhibitor IP space and will help in the design of new strategies in the discovery of inhibitors for novel kinase targets in the treatment of cancer. The generated compounds will be sold and/or out-licensed to large pharmaceutical companies for continued development. This market is currently undergoing continuous expansion due to large cuts in early drug discovery within most pharmaceutical companies. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsmedical and health sciencesclinical medicineendocrinologydiabetesmedical and health sciencesbasic medicineimmunologyautoimmune diseasesmedical and health sciencesclinical medicineoncology Programme(s) FP7-SME - Specific Programme "Capacities": Research for the benefit of SMEs Topic(s) SME-2012-1 - Research for SMEs Call for proposal FP7-SME-2012 See other projects for this call Funding Scheme BSG-SME - Research for SMEs Coordinator SAROMICS BIOSTRUCTURES AB EU contribution € 407 700,00 Address MEDICON VILLAGE 223 81 Lund Sweden See on map Region Södra Sverige Sydsverige Skåne län Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Salam Al-Karadaghi (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all PRESTWICK CHEMICAL SAS France EU contribution € 382 831,00 Address BOULEVARD GONTHIER D'ANDERNACH 67400 ILLKIRCH-GRAFFENSTADEN See on map Region Grand Est Alsace Bas-Rhin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Paul Bikard (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data KTB TUMORFORSCHUNGSGESELLSCHAFT MBH Germany EU contribution € 358 466,00 Address BREISACHER STRASSE 117 79106 FREIBURG See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Michael Kubbbutat (Dr.) Links Contact the organisation Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI TORINO Italy EU contribution No data Address VIA GIUSEPPE VERDI 8 10124 Torino See on map Region Nord-Ovest Piemonte Torino Activity type Higher or Secondary Education Establishments Administrative Contact Marco Piccinini (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France EU contribution No data Address RUE MICHEL ANGE 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Gaelle Bujan (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data WEIZMANN INSTITUTE OF SCIENCE Israel EU contribution No data Address HERZL STREET 234 7610001 Rehovot See on map Activity type Higher or Secondary Education Establishments Administrative Contact Talia Tzahor (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data