Objective Human African trypanosomiasis (HAT), known as sleeping sickness, is fatal if left untreated and a most neglected disease in Africa. An estimated 350,000 people are infected in 36 countries, the majority living in Angola, DRC, Uganda, Sudan and RoC. New di agnostics and treatments are urgently needed. Diagnostics require invasive methods and lack sensitivity and specificity. Drugs in use are old, toxic, losing efficacy, and require prolonged therapies. For over forty years, negligible clinical research has been done for new HAT treatments; thus, clinical research infrastructure and professional capacity in disease endemic countries is extremely limited. With new treatments in the pipeline, constraints in clinical evaluation and registration of new interve ntions for HAT must be urgently addressed. In August 2005, DNDi sponsored a regional workshop on HAT Clinical Trial Capacity that brought together endemic country HAT disease specialists and European clinical research and disease experts. This initial me eting resulted in the formation of a regional group who will work together to determine and implement a strategy to create sustainable regional and national clinical trial capacity for HAT. The present proposal seeks specific support for the primary acti vities of this group, which will include: HAT clinical trial methodology development Strengthening & harmonising regulatory practices throughout the region Developing strategies for national policy change Targeted HAT clinical trial capacity stren gthening Implementation will be through north-south and south-south exchange of expertise and best practice, specific training and workshops, and concurrent participation in clinical studies. Support to this project will enable the disease endemic count ries to conduct quality multicenter scale clinical trials in a timely manner with the ultimate aim of getting improved treatments registered and to patients as soon as possible. Fields of science medical and health sciencesclinical medicinepsychiatrysleep disorders Programme(s) FP6-INCO - Specific measures in support of international cooperation: Specific activities covering wider field of research under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) INCO-2002-A1.3 - Knowledge and technologies to improve control of neglected communicable diseases Call for proposal FP6-2002-INCO-DEV/SSA-1 See other projects for this call Funding Scheme SSA - Specific Support Action Coordinator DRUGS FOR NEGLECTED DISEASES INITIATIVE Address 15, chemin louis-dunant Geneva Switzerland See on map Links Website Opens in new window EU contribution € 0,00 Participants (6) Sort alphabetically Sort by EU Contribution Expand all Collapse all PROGRAMME NATIONALE DE LUTTE CONTRE LA TRYPANOSOMIASE HUMAINE AFRICAINE Democratic Republic of the Congo EU contribution € 0,00 Address Avenue de justice 123a Kinshasa-gombe See on map INSTITUTO DE COMBATE E CONTROLO DAS TRIPANOSSOMIASES Angola EU contribution € 0,00 Address 168 rua cmdt. kuenha Luanda See on map PROGRAMME NATIONAL DE LUTTE CONTRE LA TRYPANOSOMIASE Congo EU contribution € 0,00 Address Brazzaville See on map COORDINATION OFFICE FOR THE CONTROL OF TRYPANOSOMIASIS IN UGANDA Uganda EU contribution € 0,00 Address Buganda road plot 76-78 wandegeya- Kampala See on map NATIONAL RESEARCH CENTER Sudan EU contribution € 0,00 Address Khartoum See on map SWISS TROPICAL INSTITUTE Switzerland EU contribution € 0,00 Address Socinstrasse 57 Basel See on map Links Website Opens in new window
