Project description
Smart components and smart systems integration
Project aim is the development of a novel therapeutic drug monitoring point-of-care-testing (POCT) device for the measurement of immunosuppressants and related metabolites in transplanted patients. The new device will allow the automatic measurements of therapeutic drugs and metabolites characterized by a narrow therapeutic range and serious potential side effects. Clinical benefit will be an optimized dosage of the respective therapeutical drug. The patient will be connected to the device by an intravenous microdialysis catheter to allow 48-h online measurements. Based on this minimally-invasive approach, the therapeutic drugs and related metabolites will be monitored at short time intervals. The need of mixing the dialysate with the chemical reagents and the necessity of incubation times for the bioassay implementation, unavoidable procedure for bioanalyte detection, implies that a continuous measurement of such analytes is impossible, but the miniaturisation down to micro- and nano-scales will lead to very short time intervals, of the order of a few minutes. Heart of the device will be a multi-parametric optical chip, which will make use of the recent developments in nanotechnology to convert the concentration changes of the analytes in detectable luminescent signals. Essential sections of the device will be also:i) the microfluidic circuit before the chip, where the dialysate is mixed with the reagents necessary for the implementation of the biological assay;ii) the optical detection system which must be characterised by high efficiency and strong compactness;iii) the compact hardware control unit and user interface that allow instrument control and data handling.The integration of all these sections within the POCT stand-alone device requires the convergence of competences ranging from chemistry and biochemistry to optics and medicine as well as the convergence of micro and nanotechnologies, such as micro/nanofluidics,microdialysis and micro/nanosensing.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry
- engineering and technology nanotechnology
- natural sciences physical sciences optics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-ICT-2011-8
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
00185 Roma
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.