Project description Smart components and smart systems integration Show the project objective Hide the project objective Project aim is the development of a novel therapeutic drug monitoring point-of-care-testing (POCT) device for the measurement of immunosuppressants and related metabolites in transplanted patients. The new device will allow the automatic measurements of therapeutic drugs and metabolites characterized by a narrow therapeutic range and serious potential side effects. Clinical benefit will be an optimized dosage of the respective therapeutical drug. The patient will be connected to the device by an intravenous microdialysis catheter to allow 48-h online measurements. Based on this minimally-invasive approach, the therapeutic drugs and related metabolites will be monitored at short time intervals. The need of mixing the dialysate with the chemical reagents and the necessity of incubation times for the bioassay implementation, unavoidable procedure for bioanalyte detection, implies that a continuous measurement of such analytes is impossible, but the miniaturisation down to micro- and nano-scales will lead to very short time intervals, of the order of a few minutes. Heart of the device will be a multi-parametric optical chip, which will make use of the recent developments in nanotechnology to convert the concentration changes of the analytes in detectable luminescent signals. Essential sections of the device will be also:i) the microfluidic circuit before the chip, where the dialysate is mixed with the reagents necessary for the implementation of the biological assay;ii) the optical detection system which must be characterised by high efficiency and strong compactness;iii) the compact hardware control unit and user interface that allow instrument control and data handling.The integration of all these sections within the POCT stand-alone device requires the convergence of competences ranging from chemistry and biochemistry to optics and medicine as well as the convergence of micro and nanotechnologies, such as micro/nanofluidics,microdialysis and micro/nanosensing. Fields of science natural sciencesbiological sciencesbiochemistryengineering and technologynanotechnologynatural sciencesphysical sciencesoptics Programme(s) FP7-ICT - Specific Programme "Cooperation": Information and communication technologies Topic(s) ICT-2011.3.2 - Smart components and smart systems integration Call for proposal FP7-ICT-2011-8 See other projects for this call Funding Scheme CP - Collaborative project (generic) Coordinator CONSIGLIO NAZIONALE DELLE RICERCHE Address Piazzale aldo moro 7 00185 Roma Italy See on map Region Centro (IT) Lazio Roma Activity type Research Organisations Administrative Contact Paolo Di Maggio (Mr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all MICROFLUIDIC CHIPSHOP GMBH Germany EU contribution € 484 000,00 Address Stockholmer strasse 20 07747 Jena See on map Region Thüringen Thüringen Jena, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Holger Becker (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITY OF STUTTGART Germany EU contribution € 351 956,00 Address Keplerstrasse 7 70174 Stuttgart See on map Region Baden-Württemberg Stuttgart Stuttgart, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Markus B. Schubert (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data EBERHARD KARLS UNIVERSITAET TUEBINGEN Germany EU contribution € 316 320,00 Address Geschwister-scholl-platz 72074 Tuebingen See on map Region Baden-Württemberg Tübingen Tübingen, Landkreis Activity type Higher or Secondary Education Establishments Administrative Contact Guenter Gauglitz (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN Germany EU contribution € 366 800,00 Address Ismaninger strasse 22 81675 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Beate Schaulin (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSIDAD COMPLUTENSE DE MADRID Spain EU contribution € 469 440,00 Address Avenida de seneca 2 28040 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Higher or Secondary Education Establishments Administrative Contact Maribel RODRIGUEZ VILLA (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data DATAMED SRL Italy EU contribution € 396 753,00 Address Via papa giovanni xxiii 45 20090 Rodano (mi) See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Giampiero Porro (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data INESC MICROSISTEMAS E NANOTECNOLOGIAS - INSTITUTO DE ENGENHARIA DE SISTEMAS E COMPUTADORES PARA OS MICROSISTEMAS E AS NANOTECNOLOGIAS Portugal EU contribution € 344 700,00 Address Rua alves redol 9 1000 029 Lisboa See on map Region Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Activity type Research Organisations Administrative Contact Ilda Ribeiro (Mrs.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data Probe Scientific Ltd United Kingdom EU contribution € 355 200,00 Address Sir williams lyons road CV4 7EZ Coventry See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Mark O'Connell (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
