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The Developing Human Connectome Project

Objective

Few advances in neuroscience could have as much impact as a precise global description of human brain connectivity and its variability. Understanding this ‘connectome’ in detail will provide insights into fundamental neural processes and intractable neuropsychiatric diseases.
The connectome can be studied at millimetre scale in humans by neuroimaging, particularly diffusion and functional connectivity Magnetic Resonance Imaging. By linking imaging data to genetic, cognitive and environmental information it will be possible to answer previously unsolvable questions concerning normal mental functioning and intractable neuropsychiatric diseases.
Current human connectome research relates almost exclusively to the mature brain. However mental capacity and neurodevelopmental diseases are created during early development. Advances in fetal and neonatal Magnetic Resonance Imaging now allow us to undertake The Developing Human Connectome Project (dHCP) which will make major scientific progress by: creating the first 4-dimensional connectome of early life; and undertake pioneer studies into normal and abnormal development.
The dHCP will deliver:
• the first dynamic map of human brain connectivity from 20 to 44 weeks post-conceptional age, linked to imaging, clinical, behavioural and genetic information;
• comparative maps of the cerebral connectivity associated with neurodevelopmental abnormality, studying well-characterized patients with either the adverse environmental influence of preterm delivery or genetically-characterised Autistic Spectrum Disorder; and
• novel imaging and analysis methods in an open-source, outward-facing expandable informatics environment that will provide a scalable resource for the research community and advances in clinical medicine.

Field of science

  • /medical and health sciences/clinical medicine/radiology/medical imaging/magnetic resonance imaging
  • /medical and health sciences/clinical medicine
  • /natural sciences/biological sciences/neurobiology
  • /natural sciences/biological sciences/neurobiology/neuroscience

Call for proposal

ERC-2012-SyG
See other projects for this call

Funding Scheme

ERC-SyG - Synergy grant

Lead Principal Investigator

Anthony David Edwards (Prof.)

Host institution

KING'S COLLEGE LONDON
Address
Strand
WC2R 2LS London
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 8 803 608,60
Principal investigator
Joseph Vilmos Hajnal (Prof.)
Administrative Contact
Paul Labbett (Mr.)

Beneficiaries (4)

KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 8 803 608,60
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Principal investigator
Joseph Vilmos Hajnal (Prof.)
Administrative Contact
Paul Labbett (Mr.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU contribution
€ 3 240 820,40
Address
South Kensington Campus Exhibition Road
SW7 2AZ London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Shaun Power (Mr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 2 477 704
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stephen Conway (Dr.)
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 452 180
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Arthur Willemsen (Mr.)