This multidisciplinary proposal will utilize smart plasmonic concepts to solve intriguing biological and chemical problems. The plasmonic nanostructures will be arranged using biochemical linkers to provide sharp multipolar resonances which are highly sensitive to structural changes in space. The resulting plasmon rulers enable high-resolution plasmon spectroscopy and render possible optical detection of cellular activities and 3D dynamic behavior of bioentities. These smart plasmonic nanostructures will help to answer many profound questions in biochemistry that have eluded definite conclusions. These innovative concepts will pave the way towards a whole new era in research by bridging prosperous disciplines, plasmonics, physics, biology, and chemistry.
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