Objective
A significant portion of our life is spent asleep and we still do not know why. Chronic sleep deprivation and sleep disorders are experienced by millions of people in our society, and sleep loss has profound effects on brain activity and cognitive functions. Surprisingly, we still do not know what happens in the brain after sleep deprivation that makes us feel tired and impaired even in simple tasks. The objective of this project is to provide an understanding of neuronal mechanisms underlying behavioural, sensory and cognitive changes incurred after sleep deprivation, through a suite of state-of-the-art neurophysiological techniques and methodologies. We hypothesize that prior waking experience results in specific changes in the activity of cortical neuronal networks that in turn directly results in an impaired cognition and necessitates sleep. In order to address this hypothesis we will use visual stimulation, sensory gating and ‘oddball’ paradigms, spatial navigation and reaction time tasks in rats and mice in vivo. Furthermore, we will exploit conventional and conditional knock-out mouse models to investigate global and local effects of metabotropic glutamate and GABA receptors on wake- and experience-dependent changes in cortical neuronal activity during sleep deprivation. This work will not only help to explain specific mechanisms underlying behavioural and sensory deficits after sleep deprivation, but by doing so will pave the way towards more focused innovative research relevant for public health and safety.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- natural sciences biological sciences neurobiology cognitive neuroscience
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.