Objective
"The aim of this proposal is to make a major advance in understanding why some people develop diabetes despite relative leanness and why others maintain normal glucose levels despite obesity. My vision is that human genetics and the ability to study humans will provide a major leap in understanding disease mechanisms. We will use state of the art resources in genomics, metabolomics, and large human biobanks to study three stages in life that may influence predisposition to diabetes independently of obesity:
in utero life: We will test the hypothesis that the in utero environment alters offspring glucose levels and metabolism. We will perform the most comprehensive analyses of the in utero environment using mass-spectrometry based metabolomics. We will use maternal genetic factors that influence glucose levels in pregnancy to test the causal effects of the in utero environment on offspring outcomes.
“long-term” life: We will test the hypothesis that long-term exposure to altered metabolic and circulating factors influences glycaemia and metabolism. We will use the principle of Mendelian randomization to identify the subset of known and novel biomarkers that are likely to play a causal role in diabetes disease processes.
“Pre-diabetes” life: We will test the hypothesis that non-diabetic individuals carrying different type 2 diabetes genetic risk factors will have different physiological characteristics. Little is known about the detailed physiology of individuals carrying the greatest number of genetic risk factors. We will perform detailed physiological studies in non-diabetic individuals predisposed to type 2 diabetes based on specific genetic risk factors. These characteristics may inform intervention and treatment strategies targeted at those at greatest genetic risk of diabetes."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences clinical medicine obstetrics
- medical and health sciences basic medicine physiology
- medical and health sciences basic medicine medical genetics
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2012-ADG_20120314
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
EX4 4QJ Exeter
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.