Objective
"Recently germ cells biotechnology opened a new research line in aquaculture and in the conservation of genetic resources. Spermatogonia transplantation into a host species has been a valuable tool for studying processes related to spermatogenesis and is currently a powerful tool for assisted reproductive strategies. This technique represents an interesting alterative for the reproduction of Senegalese sole and meagre, two important commercial species for European aquaculture diversification. This proposal aims to enhance the production of these species, by overcoming a fundamental constraint, the capacity to successfully control reproduction in captivity. This will be accomplished by three main objectives: i) Development of molecular tools to analyse and modulate cryopreserved germ cells; ii) Development of methods to cryopreserve undifferentiated germ cells; iii) Development of reproductive strategies to create surrogate broodstocks using cryopreserved germ cells. To accomplish these objectives, Zinc/Selenium antioxidant system as well as the roles of apoptotic genes from the Bcl-2 family will be characterized in germ cells. These antioxidants were chosen due to their high capacity in protecting germ cells against reactive oxygen species (ROS) induced by cryopreservation. In vivo experiments on Zn and Se requirements will allow the formulation of specific diets to improve germ cell quality and protect cells from ROS-induced apoptosis. This part of the proposal is extremely innovative since an evaluation of germ cell quality in terms of molecular “resistance” as never been attempted. These molecular markers will allow the analysis of cryopreservation of testicular cells, establishing guidelines for the improvement of germ cell quality and determining the success of cryopreserved germ cell transplantation into host species. Transplantation of meagre and Senegalese sole spermatogonia into host species might be the solution for tackling their reproductive constraints."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- agricultural sciences agriculture, forestry, and fisheries fisheries
- natural sciences chemical sciences inorganic chemistry transition metals
- medical and health sciences health sciences nutrition
- medical and health sciences clinical medicine transplantation
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
8005-139 FARO
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.