Objective
RNA-binding proteins (RBPs) regulate the processing and expression of protein-coding transcripts. The goal of the proposed research is to develop a strategy to determine specific mRNA regulatory factors and elements important for investigating any biological processes. First, we will construct a transcriptome-wide post-transcriptional regulatory map of RBP-mRNA interactions by probabilistic modeling of protein occupancy profiles and RNA sequence data, simultaneously inferring binding locations of numerous of RBPs for a specific experimental condition. Next, we will predict specific RBPs with important regulatory functions in a different experimental setting by applying our model to protein occupancy profiles generated from different cellular conditions. Specifically, we will generate protein occupancy profiles for a human adrenocortical cell line stimulated with the primary physiological regulators of adrenal steroid hormones to examine the production of mineralocorticoids, glucocorticoids, and adrenal androgens. This research proposal necessitates a combined wet/dry approach including the complete cycle of genome-wide predictive modeling and experimental validations. The research in this proposal benefits from the molecular biology and genomics background of the Experienced Researcher combined with the computational modeling expertise of the Host Laboratory. This research has transformative potential for the field by effectively learning specific RBP-mRNA interactions from computational modeling of a single experiment.
Fields of science (EuroSciVoc)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IIF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
13125 Berlin
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.