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Content archived on 2024-06-18

ER Function In Virus Infection

Objective

A major challenge in combating significant human pathogens is the inherent variation of viruses that can evolve to evade the host immune response and antiviral treatment strategies. Our research proposes an interdisciplinary approach to identify novel antiviral targets by interrogating the host cell biology of infection by influenza A virus (IAV), human immunodeficiency virus (HIV) and hepatitis C virus (HCV) using high-throughput RNA interference (RNAi) technologies. More specifically, we propose to understand the dependency of these enveloped viruses on the host endoplasmic reticulum (ER) machinery for virus replication and propagation and how this increased virus burden activates host-ER stress, including the unfolded protein response (UPR). The UPR is implicated in inflammatory signaling and we will further investigate whether these viruses can modulate host immune responses via this pathway. In summary, we have proposed a hypothesis-driven RNAi screen to generate an overview of common host-cell factors exploited by diverse viruses during infection as well as extensive biochemical and functional validation of any sites of conserved virus-protein interactions. Therefore, this work aims to identify novel candidates for further translational research and development as improved, broad-spectrum antiviral treatments to combat infection and associated pathogenesis.

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2012-IIF
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-IIF - International Incoming Fellowships (IIF)

Coordinator

UNIVERSITEIT UTRECHT
EU contribution
€ 183 469,80
Address
HEIDELBERGLAAN 8
3584 CS Utrecht
Netherlands

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Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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