Objective
Our understanding of microbial genetic diversity in nature and how it relates to phenotypic divergence is extremely limited, including for social traits like those exhibited by myxobacteria. Relying on next-generation sequencing, the project proposed here seeks to quantify the roles that the forces of evolution play in shaping genomic and social divergence in natural populations of the model cooperative myxobacterium, Myxoccocus xanthus. First, I will use a global and spatially hierarchical collection of natural isolates spanning large metric scales to grasp both total and spatially partitioned genetic diversity in M. xanthus. Second, I will analyze genetic substitution patterns among these natural isolates, and quantify signals of selection and drift under special consideration of a “gold-standard” mutation rate estimate directly inferred from whole genome sequences of a large collection of lab evolved strains of M. xanthus. Third, I will link previously published phenotypic patterns in closely related natural isolates to their whole genome data to infer their underlying molecular mechanisms, and candidate mutations will be tested directly through construction of isogenic clones in the lab. This proposal offers me the excellent opportunity to receive cutting-edge training at one of Europe’s elite universities and will increase my level of scientific maturity and independence. It will also contribute European excellence in applying cutting-edge technologies to conceptually important questions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences evolutionary biology
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
8092 Zuerich
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.