Objetivo
Focusing light to the (sub)micron scale is the enabling element in many important biomedical and industrial applications, such as optical microscopy and laser nano-surgery. However, the inherent inhomogeneity of biological tissues induces light scattering which limits effective focusing to shallow depths of a few hundred microns. As a result, optical microscopy, perhaps the most important tool in biological discovery and medical investigation, is currently restricted to superficial investigation. Nevertheless, recent results have shown that the effects of such “random” scattering can be undone, controlled, and even exploited by high-resolution wavefront shaping. The goal of this project is to use these novel insights to break the resolution limit of deep-tissue optical techniques, and enable controlled sub-micron focusing and microscopic imaging deep in scattering media. This ambitious goal will be achieved by combining the powerful techniques of the emerging field of “wavefront shaping” where leading contributions have been made by the applicant and the host, with the penetration depth allowed by photoacoustics, field in which the host has a world-leading expertise. We will be able to go beyond the acoustic wavelength resolution limit of photoacoustics by exploiting nonlinear photoacoustic effects as the control signal for adaptive light focusing, an original insight discovered by the joint work of the applicant and the host in the last few months. Achieving the project’s goal would be both a scientific and technological breakthrough as well as a having a huge potential impact on societal issues, with the hope of substituting invasive biopsy procedures and allowing imaging through complex samples in industry.
Ámbito científico (EuroSciVoc)
CORDIS clasifica los proyectos con EuroSciVoc, una taxonomía plurilingüe de ámbitos científicos, mediante un proceso semiautomático basado en técnicas de procesamiento del lenguaje natural. Véase: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS clasifica los proyectos con EuroSciVoc, una taxonomía plurilingüe de ámbitos científicos, mediante un proceso semiautomático basado en técnicas de procesamiento del lenguaje natural. Véase: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- ciencias naturalesciencias físicasópticamicroscopía
- ciencias naturalesciencias físicasópticafísica del láser
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Tema(s)
Convocatoria de propuestas
FP7-PEOPLE-2012-IEF
Consulte otros proyectos de esta convocatoria
Régimen de financiación
MC-IEF -Coordinador
75794 Paris
Francia