Objective
My research will use integrative modeling of the interactions of the molecular elements to develop a more complete understanding of dynamic cellular signalling and information processing mechanisms. It will focus on information content of collected biological data, predictive power of developed models and gaining control over studied systems. This will be achieved via mathematically designed experimental protocols executed using microfluidic devices. A system of NF-kB signalling with TNF stimulation will serve as an initial model to develop theoretical and experimental tools. Methodology will be then utilized to better understand principles of LPS-IRF3 signalling.
The complexity of biochemical systems causes informative experimentation to be a difficult task and makes mathematical modelling necessary to explain collected data. Unfortunately, selecting an appropriate model is usually problematic. Even measurements of all components of a dynamic biochemical system, do not allow for its reverse-engineering if observed only in a small number of experimental conditions. The only possibility to overcome the selectivity of available data is to perturb a system in a way that reveals desired information. The ability of microfluidics to generate spatial and temporal perturbations in extracellular environments provides a unique tool for execution of carefully designed stimuli.
In my research, I will combine methods of experimental design with new possibilities of microfluidic devices in order to increase the predictive power of biochemical dynamical models and gain control over studied systems in vitro. The ability to control biological systems is essential to guide drug target selection and design new effective therapies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences classical mechanics fluid mechanics microfluidics
- natural sciences computer and information sciences data science data processing
- natural sciences mathematics applied mathematics mathematical model
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2012-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
02-106 WARSZAWA
Poland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.