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Content archived on 2024-06-18

The role of neuronal intracellular traffic in Alzheimer´s disease

Objective

In neurons of Alzheimer’s disease (AD) there is an aberrant accumulation of beta-amyloid (Aβ) at synapses that renders difficult the formation of new memories for AD patients. Intracellular trafficking abnormalities have been implicated in Aβ accumulation. This research project aims to define how neuronal intracellular trafficking is mechanistically involved in Aβ accumulation that leads to AD. We will determine how the intracellular itinerary of the amyloid precursor protein in neurons influences the generation of Aβ. We will determine the intracellular trafficking of lysosomal hydrolases in neurons and their contribution to the lysosomal clearance of Aβ. Furthermore, we will investigate the mechanism whereby regulators of intracellular trafficking identified as risk-factors for AD contribute to Aβ accumulation. Finally, because aging is the most important risk factor for AD, we will determine if alterations in intracellular trafficking occur in aging, identifying a new mechanism of vulnerability to neurodegeneration in AD. Thus, we will demonstrate how intracellular trafficking is implicated in AD and unravel an important disease mechanism.

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP7-PEOPLE-2012-CIG
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

MC-CIG - Support for training and career development of researcher (CIG)

Coordinator

FACULDADE DE CIENCIAS MEDICAS DA UNIVERSIDADE NOVA DE LISBOA
EU contribution
€ 100 000,00
Address
CAMPO MARTIRES DA PATRIA 130
1169 056 LISBOA
Portugal

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Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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