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Systematic investigation of epistasis in molecular evolution

Objective

Why does a mutation have a deleterious effect when it occurs in one species but shows no apparent consequences on the phenotype when it occurs in another species? What are some of possible explanations on the molecular basis of this phenomenon? Are the computational predictions of the extent of this phenomenon in nature accurate? The present project aims to take a swing at answering, at least partially, these basic questions of epistasis in molecular evolution. Within our work we plan to address these issues using computational approaches, systematic fitness assays of engineered orthologous genotypes and experimental functional assays of specific cases of epistasis identified by evolutionary analysis. By tackling these goals and utilising this array of approaches the projects aims to create a synthesis between theory and experimentation under the confines of a single laboratory that will allow us to study this phenomenon in a systematic fashion on the interface of different fields and methodologies.

Field of science

  • /natural sciences/biological sciences/genetics and heredity/mutation
  • /natural sciences/biological sciences/molecular biology/molecular evolution

Call for proposal

ERC-2013-StG
See other projects for this call

Funding Scheme

ERC-SG - ERC Starting Grant

Host institution

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
Address
Am Campus 1
3400 Klosterneuburg
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 303 788,58
Principal investigator
Fyodor Kondrashov (Dr.)
Administrative Contact
Barbara Abraham (Mrs.)

Beneficiaries (2)

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
Austria
EU contribution
€ 303 788,58
Address
Am Campus 1
3400 Klosterneuburg
Activity type
Higher or Secondary Education Establishments
Principal investigator
Fyodor Kondrashov (Dr.)
Administrative Contact
Barbara Abraham (Mrs.)
FUNDACIO CENTRE DE REGULACIO GENOMICA

Participation ended

Spain
EU contribution
€ 1 157 787,42
Address
Carrer Doctor Aiguader 88
08003 Barcelona
Activity type
Research Organisations
Administrative Contact
Olga Juderías (Ms.)