Objective
The overall goal of this Research Training Network (RTN) is to gain a quantitative understanding of the nature and evolution of protein interaction networks in eukaryotes. This will require the application of a broad range of methods and technologies, thus providing a unique opportunity for interdisciplinary training of early-stage and experienced researchers.
The RTN focuses on the study of the interplay between Src Homology 3 (SH3) domains, their host proteins and their binding partners (or target ligands) in four different yeast species, i.e. Saccharomyces cerevisiae (the best studied eukaryotic cell which exclusively profilerates by budding), Candida albicans (a human pathogen able to switch between bud-like and hyphal growth), Ashbya gossypii (a plant p athogen which exclusively grows like filamentous fungus), and Schizosaccharomyces pombe (the second best studied yeast which profilerates by bipolar growth and fission). These yeasts encompass a thousand million years of evolution.
The RTN intends to characterize the presently known interactions and to identify hitherto undetected interactions. Comparative analyses across the four genomes will allow us to investigate how new interactions were added to a network to cope with new necessities, as well as how t hey were lost when they were not needed anymore. The RTN will train researchers to be able to use a combination of approaches ranging from structural biology, biochemistry, genetics and genomics to advanced light microscopy and simulation tools for cell networks. To achieve these objectives a multidisciplinary approach will be carried out, by bringing together the expertise of leading research groups at a multilateral level.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell signaling
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences molecular biology structural biology
- natural sciences computer and information sciences software software applications simulation software
- natural sciences biological sciences genetics genomes eukaryotic genomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-1
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.