Objective
Coeliac disease (CD) is a chronic disorder caused by hypersensitivity to some of the most common proteins (gluten) in the diet of the European population. CD affects as much as 1% of the Europeans (2.5 million people) and is the most common food intolerance in Europe. If recognised, CD patients have only limited access to safe foods and there is no causal therapy available. The general objective of this STREP is to significantly reduce the number of people suffering from CD in Europe, by developing primary prevention strategies for CD. By European collaboration of leaders from disciplines beyond those traditionally used, a.o. from academia, patient organisations and industry, we will carry out innovative research to examine the hypothesis that it is possible to induce tolerance for gluten in genetically predisposed children through the introduction of small quantities of gluten during the period of breast-feeding. Measurable objectives are: 1) Taking full advantage of genomics techniques: Identification of the immunological mechanisms involved in initiating the aberrant response to gluten introduction in the diet of infants genetically predisposed to CD; 2) Identification of the factors in the early dietary history involved in the aberrant response to gluten in children; 3) Development of new European guidelines for early nutrition in order to prevent CD. To achieve our objectives we propose the following structure and methodology: I) A prospective, randomized, blind dietary intervention study in 1000 young children from high-risk families for CD, to asses the possibilities to induce immune tolerance for gluten in genetically predisposed children; II) A follow-up population study in 16.000 children aged 12 years, born during and after the Swedish epidemic of CD, to asses the late effect of dietary history, concerning gluten exposure and breast-feeding, on the development of CD and related autoimmune phenomena.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- humanities history and archaeology history
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences health sciences nutrition
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-FOOD-4-B
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
9600 LEIDEN
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.