Objective
The primary objective of this proposal is to support the applicant's professional reintegration in a European host academic institution (DMBG, University of Thrace, Greece) in order to pursue an academic career. This objective will be met by establishing independent research in the host institution from which the applicant has already been offered a three-year contract. The proposed research project falls within the general thematic area of life sciences and improving quality of life, which is supported by the Community. It focuses on investigating the role and mechanism(s) of aldehyde dehydrogenase 3A1 (ALDH3A1) in protecting the eye from UV damage, which is of high relevance of human health and prevention of eye-related diseases. ALDH3A1, a detoxifying enzyme, is recruited in the corneal epithelium as a crystalline protein with additional functions beyond its metabolic role, which remain to be determined. Previous results demonstrated that ALDH3A1 confers resistance against UV- and 4-hydroxynonenal-induced a poptosis, mainly by metabolising toxic lipid peroxidation aldehydes. However, a recently proposed novel role of ALDH3A1 as a negative cell cycle regulator in corneal epithelial cells further supports its protective function in the cornea and reveals its multifunctional character.
The hypothesis to be tested is that ALDH3A1 modulates cell cycle and apoptotic cascades in order to allow for DNA repair, and thus, promotes cell survival in response to UV-induced oxidative damage. A number of studies are proposed to identify the underlying mechanisms involved in ALDH3A1 protection against such damage. To pursue the goals of this project, isogenic cell lines along with techniques to assess growth control, apoptosis and DNA repair will be employed. Accomplishment of the proposed studies will facilitate the applicant's successful reintegration, while transfer of the acquired knowledge to the host institution will contribute to promoting excellence in European research.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences organic chemistry aldehydes
- natural sciences biological sciences genetics DNA
- medical and health sciences basic medicine physiology pathophysiology
- medical and health sciences clinical medicine ophthalmology
- medical and health sciences basic medicine physiology homeostasis
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
KOMOTINI
Greece
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.