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Development of marker vaccines, companion diagnostic tests and improvement of epidemiological knowledge to facilitate control of rinderpest and peste des petits ruminants viruses

Objective

Rinderpest (RP) and peste des petits ruminants (PPR) control is considered a priority in the countries where the diseases are endemic (Africa, Middle East and West Asia). Because of their high mortality and high morbidity rates, RP and PPR are dreaded animal diseases included in the list A of the Office International des Epizooties, list of dangerous animal pathogens where extremely contagious animal diseases of high economic importance are grouped. Effective control of RP and PPR by vaccination, through international funding, mainly by the EU, contributes to increasing and sustaining livestock and ensures world food security. In the present proposal, the first objective is to develop marker vaccines capable of preventing RP and PPR infections and also companion diagnostic tests to differentiate between infected and vaccinated animals. This differentiation is of major importance for eradication programmes because it would allow more precise targeting of vaccination while serosurveillance of the disease could be maintained through the use of companion diagnostic tests. This would allow for a quicker lifting of control measures. Through reverse genetics technology it is also aimed to improve the quality of these marker vaccines derived from current attenuated strains. Another objective of the proposal is to use improved epidemiological information systems for a better analysis of the current situation for rinderpest and PPR and for predicting the impact of vaccination strategies on the control of the two diseases. Thus the expected outputs from this proposal will give additional support to some existing EU developing country programmes.

Call for proposal

FP6-2002-INCO-DEV-1
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Funding Scheme

STREP - Specific Targeted Research Project

Coordinator

CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LE DEVELOPPEMENT
Address
Rue Scheffer 42
Paris
France

Participants (8)

AFRICAN UNION - INTER-AFRICAN BUREAU FOR ANIMAL RESOURCES
Kenya
Address
Museum Hill,westlands Road
Nairobi
FOOD AND AGRICULTURE ORGANISATION OF THE UNITED NATIONS
Italy
Address
Viale Delle Terme Di Caracalla
Rome
INSTITUTE FOR ANIMAL HEALTH - PIRBRIGHT LABORATORY
Address
High Street
Compton, Nr Newbury
INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLÖGICA
Portugal
Address
Av. Da Repûblica - Ean - Qta. Do Marquês, Ap. 12
Oeiras
KENYAN AGRICULTURE RESEARCH INSTITUTE
Kenya
Address
Kaptagat Road
Nairobi
LABORATOIRE CENTRAL VETERINAIRE BAMAKO
Mali
Address
Km 8, Route De Koulikoro
Bamako
NATIONAL VETERINARY INSTITUTE
Ethiopia
Address

Debre-zeit
THE ROYAL VETERINARY COLLEGE
Address
Royal College Street
London