Rinderpest (RP) and peste des petits ruminants (PPR) control is considered a priority in the countries where the diseases are endemic (Africa, Middle East and West Asia). Because of their high mortality and high morbidity rates, RP and PPR are dreaded animal diseases included in the list A of the Office International des Epizooties, list of dangerous animal pathogens where extremely contagious animal diseases of high economic importance are grouped. Effective control of RP and PPR by vaccination, through international funding, mainly by the EU, contributes to increasing and sustaining livestock and ensures world food security. In the present proposal, the first objective is to develop marker vaccines capable of preventing RP and PPR infections and also companion diagnostic tests to differentiate between infected and vaccinated animals. This differentiation is of major importance for eradication programmes because it would allow more precise targeting of vaccination while serosurveillance of the disease could be maintained through the use of companion diagnostic tests. This would allow for a quicker lifting of control measures. Through reverse genetics technology it is also aimed to improve the quality of these marker vaccines derived from current attenuated strains. Another objective of the proposal is to use improved epidemiological information systems for a better analysis of the current situation for rinderpest and PPR and for predicting the impact of vaccination strategies on the control of the two diseases. Thus the expected outputs from this proposal will give additional support to some existing EU developing country programmes.
Call for proposal
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Funding SchemeSTREP - Specific Targeted Research Project