Objective
PROLIGEN aims to enhance the endogenous regenerative capacity of injured kidneys based on information derived from genomics/proteomics and functional genomics. The approach of PROLIGEN is: a) To define and identify set of genes/proteins associated with functional recovery from renal injury. b) To build up high throughput test systems to follow the basic biological process involved in regeneration and to use these read out systems for functional genomics. And c) to develop biologicals and cell based therapy to foster proliferation. PROLIGEN differs from previous approaches in that we split the regeneration process into the different main biological process (apoptosis, formation of pro- versus anti-inflammatory mediators/macrophage phenotype and cell proliferation), and we aim to study regeneration as the result of their interdependence. We take into account that macrophages are at the centre of a complex regulatory network receiving and distributing signals from and to all biological process, thus affecting recovery. At variance with previous studies we particularly focus not only on the identification of markers relevant for regeneration rather than the use of functional genomic technology which provide a new network of gene function and new platforms to deliver a new cellular based therapy strategy. Experiments will be carried out in vivo and in vitro using rodent, tubular cell and macrophage culture. Genomics, functional genomics and recombinant protein synthesis SMEs and prominent experts in fundamental biological process associated to the renal ischemia/reperfusion and regeneration processes will provide the necessary knowledge and critical mass to reach the goal of this project; namely and foremost, the development of intervention strategies for amelioration of acute renal failure and promotion of regeneration and healing.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- medical and health sciences health sciences public health
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences medical biotechnology cells technologies
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.