Objective
Parkinson disease (PD), a specific type of a group of neurodegenerative disorders called synucleinopathies, is the second most common neurodegenerative disorder worldwide. Many neurodegenerative disorders are preceded by a pre-symptomatic phase, probably lasting years, during which degeneration and death of neurons occurs before any clinical symptoms appear. One major goal of clinical research is to improve early detection of these diseases by developing tools to move diagnosis backward in the neurodegeneration temporal course. Thus, the central objective of this INDABIP proposal is the identification of molecular markers that hallmark the onset of a cellular dysfunction in the brain areas involved in PD. These markers would enable to identify at-risk groups both for disease onset and progression during the pre-clinical period. INDABIP combines in a very unique form the latest technologies in biomarkers research provided by the companies to be applied on invaluable human material in one of the largest brain tissue collection ever approached combined finally with further research and validation on cell and in vivo models. Within our consortium we will have access to more than 120 neuropathologically-confirmed brains in Barcelona, Munich and from Brain-Net Germany. The putative biomarkers will be analyzed boinformatically and the more promising ones submitted to a validation program including quantitative PCR, WB and inmunohistochemistry confirmation. Additionally, a careful assessment for the potential as pharmacological targets will be done on the obtained biomarkers.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences basic medicine neurology dementia alzheimer
- medical and health sciences basic medicine physiology
- medical and health sciences basic medicine neurology parkinson
- natural sciences biological sciences genetics genomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BARCELONA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.