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Archive's tissues: improving molecular medicine research and clinical practice

Objective

Nowadays, emerging capabilities are being introduced to a more personalized molecular approach in medicine with individual risk assessment and best suited care. An important tool for translational research in this field is the large number of human archive tissues (AT), with any kind of disease, stored in hospitals all over Europe. Tissues from biopsies or surgical therapy are fixed and paraffin embedded to obtain a histopathology diagnosis, and then stored in archives for many decades. We developed already the technology that allows molecular research at DNA and RNA level in paraffin embedded tissues, so that the findings can be evaluated in the proper context. These methods were first designed by European scientists. In this way it is easy to study lesions with long follow-up, rare diseases, viral persistence or molecular pattern of lesions with known therapy outcomes. There is the opportunity of an European Coordination Action in advanced genomics to improve and speed up clinical applications for health and also for R&D of European biotechnology companies.
The objectives of this CA are: a) to prepare molecular methods validation and standardization for AT; b) dissemination of standardized methods for functional genomics at European level with good practice rules; c) prepare future perspectives at clinical, research and technology level; d) establish bioethics guidelines for utilization of human archive tissues in research; e) organize tissues banks for translational research; f) promote technology innovation and industrial collaboration. Expected results of the Action are integrating European molecular research with a faster dissemination and application of molecular methods in clinical practice, preparing the opportunity of new multicentric functional genomics research projects, stimulating technology innovation with industrial collaboration in the fields of gene expression analysis and proteomics...

Call for proposal

FP6-2005-LIFESCIHEALTH-6
See other projects for this call

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Coordinator

CONSORZIO PER L'AREA DI RICERCA SCIENTIFICA E TECNOLOGICA DI TRIESTE'
Address
Padriciano 99
Trieste
Italy

Participants (20)

STICHTING KATHOLIEKE UNIVERSITEIT, MORE PARTICULARLY: UNIVERSITY MEDICAL CENTRE NIJMEGEN
Netherlands
Address
Geert Grooteplein 10
9101 Nijmegen
INSTITUTO DE PATOLOGIA E IMUNOLOGIA MOLECULAR DA UNIVESIDADE DO PORTO
Portugal
Address
Rua Dr. Roberto Frias S/n
Porto
 
UNIVERSITE DE LAUSANNE
Switzerland
Address
Batiment Du Rectorat Et De L'administration (Bra)
Lausanne
UNIVERSITY OF PISA
Italy
Address
Lungarno Pacinotti
Pisa
 
MEDIZINISCHE UNIVERSITAET INNSBRUCK
Austria
Address
Chrisph-probst Platz 1
Innsbruck
 
TECHNISCHE UNIVERSITAET MUENCHEN
Germany
Address
Arcistrasse 21
Munich
INSTITUT DE RECERCA DE L'HOSPITAL DE LA SANTA CREU I SANT PAU
Spain
Address
Sant Antoni M. Claret, 167
Barcelona
CHARITE - UNIVERSITATSMEDIZIN BERLIN
Germany
Address
Schumannstr. 20-21
Berlin
 
UNIVERSITA' DEGLI STUDI DI TORINO
Italy
Address
Via Giuseppe Verdi 8
Torino
MILESTONE S.R.L.
Italy
Address
Via Fatebenefratelli 1
Sorisole- Bergamo
KLINIAKE BOLNICE "SESTRE MILOSRDNICE"
Croatia
Address
Vinogradska Cesta 29
Zagreb
 
UNIVERZA V LJUBLJANI
Slovenia
Address
Korytkova 2
2212 Ljubljana
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
France
Address
Rue Michel-ange 3
Paris
 
MEDICAL UNIVERSITY OF WROCLAW
Poland
Address
Pasteura 1
Wroclaw
MEDIZINISCHE UNIVERSITAET GRAZ
Austria
Address
Universitatsplatz 1
Graz
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
Address
Geschwister-scholl-platz 1
Muenchen
 
INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY
Italy
Address
Padriciano 99
Trieste
UNIVERSITAT DE VALENCIA
Spain
Address
Blasco Ibanez 13, Avenida
Valencia
HOSPITAL CLINIC BARCELONA
Spain
Address
Villarroel 170
Barcelona
UNIVERSITA' DEGLI STUDI DI VERONA
Italy
Address
Via Dell'artigliere 8
Verona