Objective
Tuberculosis causes more deaths world-wide than almost any other infectious agent, with nearly two million deaths per year and devastating impact in developing countries. More effective means of medical intervention are required both to reduce the number of deaths from tuberculosis and to allow more effective treatment of drug-resistant infections.
The TB-DRUG project aims to discover novel lead compounds against Mycobacterium tuberculosis, to be developed into products that can alleviate the global burden of tuberculosis, by carefully selecting proteins to be taken into the drug discovery process as novel targets. In anticipation of the significant attrition rate of the drug discovery process, we suggest to include different targets in the earliest stages of drug development, followed by a more focused approach on the most promising candidates in the later stages.
The plan of action is to express and purify each protein being targeted using available expression systems, to determine the structure of each protein by X-ray crystallography, to develop biochemical assays suitable for adaptation to high-throughput (HTS) screening, to screen for and identify inhibitors for each protein where a suitable assay has been developed, to assess the effectiveness of the best inhibitors identified against live M. tuberculosis in-vitro. By bringing together scientists from many different disciplines, and by connecting academics with industry research, TB-DRUG establishes an integrated drug discovery and development process.
The range of complementary expertise available within the proposed Project, together with a state-of-the-art discovery technology, facilitates the entire process of preclinical drug discovery. The TB-DRUG Consortium strives to have a significant impact in the area of tuberculosis drug development and to contribute to the education of young scientists offering exceptional teaching and training opportunities for post-doctoral fellows and PhD students.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences earth and related environmental sciences geology mineralogy crystallography
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine pneumology tuberculosis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
BUDAPEST
Hungary
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.