Objective
The objective of CAPPELLA is to develop a series of innovative small-ligand tools and libraries that allow new approaches to the inhibition of protein:protein interactions (PPI) in cancer.The inhibition of PPI is one of the most promising approaches to the development of novel cancer therapies. Because many PPI occur within the cell they can only be targeted by small molecules. But because PPI differ structurally from more classic drug targets such as enzymes and receptors, existing compounds have generally delivered disappointing results. New approaches are needed. The partners are "state of the art" in the research areas addressed. The project is a unique opportuniy to integrate novel insilico, chemical, genetic and ADME-based approaches to the design, synthesis and optimization of libraries and compounds. A key theme is the utilization of structural motifs found in natural PPI inhibitor compounds. This is coupled with high tent testing of the resultant structures on 3 distinct PPI targets relevant to different types of cancer, to allow compound rule-sets to be developed and improved. This project brings together some of Europe's leading biotech SMEs and several highly recognised academic institutes. By combining 5 distinct chemical approaches and testing them on 3 different targets (all from different partners) in three successive but repeating cycles the project mobilises resources from across Europe. All 9 partners have experienced teams and the coordinator's staff has experience of 7 prior EU projects. Each year there are about 10.9 million new cases of cancer and 6.7 million deaths. In Europe, 46% of cases are in women. By providing new approaches to a promising but challenging target class, perhaps 50% of cancer patients could one day benefit from the findings. The project provides the individual partners, and the European biotech industry, with tools and compounds having a high market potential and strengthening their competitive advantage.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences basic medicine medicinal chemistry
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine physiology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ALLSCHWIL
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.