Objective
Treatment of embryonal tumours (ET) is a challenge for the pediatric oncologist. Innovative translational research is required to exploit available genomic data and implement state-of-the-art technologies to overcome the deficits of current diagnostic and treatment strategies. We will set up a consortium of leading European institutions and SMEs with extensive clinical and technological expertise to establish a unique pipeline for the comprehensive development and validation of novel diagnostic tools in addition to efficient preclinical drug development for ET. Our holistic approach includes: 1) Validation of a chip-based diagnostic platform tailored specifically for ET including analysis of genes previously shown by the consortium to be affected in ET 2) Generation of ET-specific data on novel array-based platforms for the development of diagnostics at the microRNA and serum proteomics levels 3) Extension of an existing database designed to warehouse complete clinical and experimental data for neuroblastoma to include all ET entities 4) Implementation of a virtual ET-Biobank to improve sharing of patient samples 5) Functional characterisation of the most promising molecular targets previously identified by the partners as a foundation for entry into a drug development pipeline 6) Integration of existing disease-specific mouse models to evaluate new treatment modalities in vivo 7) Development and initial evaluation of an antibody affecting ET invasiveness 8) Application of novel bioinformatic solutions for the meta-analyses 9) Dissemination of the novel tools to researchers and clinical study centers in Europe Our coordinated effort can achieve the critical mass to facilitate the necessary integration of research capacities for translating ET genome data into significant medical progress. Involvement of clinical study centers will ensure a direct link to the bedside, aimed at improving child health and quality of life.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences computer and information sciences data science
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences clinical medicine oncology lung cancer
- medical and health sciences clinical medicine oncology skin cancer melanoma
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-6
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ESSEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.