Objective
A programme is proposed, by an established European consortium, that will exploit advances in complex trait genetics and functional genomics to discover novel susceptibility genes for coronary artery disease (CAD). The aim is to identify novel proteins and pathways implicated in atherosclerosis and arterial thrombosis in order to define new targets for prevention and treatment and to devise diagnostic tools that identify disease mechanisms in individuals. The PROCARDIS programme has assembled a uniquely large and carefully phenotyped collection of subjects with early CAD: >2600 affected sibling pairs; >1300 two generation 'trios'; > 5000 genetically enriched cases; >5000 matched controls free from CAD. A genome-wide linkage screen has been completed, identifying and replicating a novel locus on chromosome 17; genetic association has already been demonstrated within this, and another, locus. The proposed second phase of PROCARDIS will incorporate: a definitive genome-wide association analysis, substantial new investment in bioinformatics and functional genomics platforms (as will be needed to exploit the linkage and association data), and measurement of novel intermediate phenotypes that will yield biomarkers for CAD risk and quantitative traits for genetic analysis. Additional academic and SME partners have been selected to reinforce the existing consortium, each with unique and complementary expertise, to address the needs of post-genome research. PROCARDIS will integrate a critical mass to attain ambitious and clearly defined objectives; by adopting parallel approaches, the PROCARDIS programme can include 'higher risk' components without endangering the overall outcome. The results will address a priority theme, will give impetus to Europe's competitiveness and will satisfy major societal needs'.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics chromosomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OXFORD
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.