Objective A programme is proposed, by an established European consortium, that will exploit advances in complex trait genetics and functional genomics to discover novel susceptibility genes for coronary artery disease (CAD). The aim is to identify novel proteins and pathways implicated in atherosclerosis and arterial thrombosis in order to define new targets for prevention and treatment and to devise diagnostic tools that identify disease mechanisms in individuals. The PROCARDIS programme has assembled a uniquely large and carefully phenotyped collection of subjects with early CAD: >2600 affected sibling pairs; >1300 two generation 'trios'; > 5000 genetically enriched cases; >5000 matched controls free from CAD. A genome-wide linkage screen has been completed, identifying and replicating a novel locus on chromosome 17; genetic association has already been demonstrated within this, and another, locus. The proposed second phase of PROCARDIS will incorporate: a definitive genome-wide association analysis, substantial new investment in bioinformatics and functional genomics platforms (as will be needed to exploit the linkage and association data), and measurement of novel intermediate phenotypes that will yield biomarkers for CAD risk and quantitative traits for genetic analysis. Additional academic and SME partners have been selected to reinforce the existing consortium, each with unique and complementary expertise, to address the needs of post-genome research. PROCARDIS will integrate a critical mass to attain ambitious and clearly defined objectives; by adopting parallel approaches, the PROCARDIS programme can include 'higher risk' components without endangering the overall outcome. The results will address a priority theme, will give impetus to Europe's competitiveness and will satisfy major societal needs'. Fields of science medical and health sciencesclinical medicineangiologyvascular diseasesmedical and health sciencesclinical medicinecardiologycardiovascular diseasesarteriosclerosisnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencesgeneticschromosomes Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2005-2.1.1-1 - Genome-wide mapping and functional genomics of susceptibility to coronary artery disease Call for proposal FP6-2005-LIFESCIHEALTH-6 See other projects for this call Funding Scheme IP - Integrated Project Coordinator THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD EU contribution No data Address University Offices, Wellington Square OXFORD United Kingdom See on map Total cost No data Participants (14) Sort alphabetically Sort by EU Contribution Expand all Collapse all KAROLINSKA INSTITUTET Sweden EU contribution No data Address Nobelsväg 5 STOCKHOLM See on map Total cost No data ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI Italy EU contribution No data Address Via Eritrea, 62 MILANO See on map Total cost No data CONSORTIUM NATIONAL DE RECHERCHE EN GENOMIQUE - CNG France EU contribution No data Address 2 rue Gaston Cremieux CP 5721 EVRY See on map Total cost No data INSTITUT DE RECERCA DEL HOSPITAL DE LA SANTA CREU I SANT PAU Spain EU contribution No data Address C/ Sant Antoni M Claret, 167 BARCELONA See on map Total cost No data UNIVERSITÀ DEGLI STUDI DI MILANO Italy EU contribution No data Address Via Festa del Perdono, 7 MILANO See on map Total cost No data CLINICAL GENE NETWORKS AB Sweden EU contribution No data Address Karolinska Science Park, Fogdevreten 2B STOCKHOLM See on map Total cost No data ASTRAZENECA Sweden EU contribution No data Address Västra Mälarhamnen SÖDERTÄLJE See on map Total cost No data DIGILAB BIOVISION GMBH Germany EU contribution No data Address Feodor-Lynen-Strasse 5 HANNOVER See on map Total cost No data METABOMETRIX LIMITED United Kingdom EU contribution No data Address RSM, Prince Consort Road LONDON See on map Links Website Opens in new window Total cost No data COMMISSARIAT A L'ENERGIE ATOMIQUE France EU contribution No data Address Batiment Le Ponant D - 25 rue Le Blanc PARIS See on map Links Website Opens in new window Total cost No data THE UNIVERSITY OF SURREY United Kingdom EU contribution No data Address Stag Hill GUILDFORD See on map Total cost No data UPPSALA UNIVERSITET Sweden EU contribution No data Address St Olofsgatan 10B 256 UPPSALA See on map Total cost No data GESELLSCHAFT FÜR ARTERIOSKLEROSEFORSCHUNG E.V. Germany EU contribution No data Address Domagkstrasse 3 MÜNSTER See on map Total cost No data CF CONSULTING FINANZIAMENTI UNIONE EUROPEA SRL Italy EU contribution No data Address Via Giuseppe Mussi 1 MILANO See on map Links Website Opens in new window Total cost No data
