Objectif
Background:During the last years some respiratory viruses (HMPV/hCoV-NL63/SARS/Bocavirus/flu H5N1) emerged. In addition to other viruses (RSV, EBV, Paramyxoviruses) they are able to induce severe respiratory diseases in high risk patients, mainly young children and elderly.
Approach: We will study the innate and acquired immune response of elderly against these viruses. Clinical and basic research aspects will be addressed equally, while also new diagnostic assays for the evaluation of the immune status of elderly will be developed. Within the project an animal model for the investigation of the elderly's immune response to those viruses will be established. In this model antiviral agents will be tested for their ability to support the patient's immune response. Up to 40.000 elderly sera collected during the last 9 years will be tested for antibodies to emerging respiratory viruses (HCoV-NL63/HMPV/RSV/EBV/flu H5N1), providing a wide view of these virus epidemiology; immune cell response against the above viruses, an aged animal model for studying the immune response in vivo and testing antivirals or immune stimulators and new ELISA assays for testing host antibodies against new viruses will be investigated. For a precise view on the elderly's immune response to those viruses, a defined and uniform panel of relevant clinical data related to respiratory infections will be collected. For this internationally standardized prospective data mining a new multi-lingual software tool will be developed within the project and used by the partners.
Expected results: We expect to gain detailed knowledge on the innate and acquired immune response to emerging respiratory viruses in elderly. A thorough basic investigation of emerging respiratory viruses will provide further handles to develop antiviral strategies, and (known) antivirals will be evaluated with the final goal to support the elderly's immune response while reducing the mortality of respiratory infections in elderly'
Champ scientifique (EuroSciVoc)
CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN. Voir: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN. Voir: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
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Thème(s)
Appel à propositions
FP6-2005-LIFESCIHEALTH-7
Voir d’autres projets de cet appel
Régime de financement
STREP -Coordinateur
BONN
Allemagne