Objective
Modification of cells is a central topic in pharmaceutical and medical sciences as well as in basic research. Innumerable opportunities, e.g. in discovery of new regulatory pathways, novel targets, and potential drug candidates as well as clarification of signal transduction are addressed by cell transfection technology. The dominant consideration for cell manipulation is the type of cells used. Until now, most often conventional, immortal cell lines, being cultured for years or even decades in flasks, have been assigned to this specified use, although they are mainly irrelevant in physiological and medical respects. The optimal choice would be primary cells, since they are distinctly closer to the physiological situation than cell lines. Researchers would made rapid strides in the analysis of the biology of cells among others for the development of therapeutics, and new types of treatments as well as possible cures for a variety of diseases and injuries would be possible by using primary cells instead of cell lines. However, primary cells until recently were hard or often even impossible to transfect by non-viral methods, and consequently, many researchers still hesitate to adopt these cells despite their unquestionable advantages. With the advent of the nucleofection technology, a unique method for the highly efficient transfection of primary cells was recently made available to the life science community.
With MODEST the main objectives are i) the development of devices for ultrahigh-throughput nucleofection of primary cells in modular multi-well plates, and ii) the application of this technology to the highly relevant area of immunological as well as neuronal disorders to facilitate investigations of possible mechanisms of intervention.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-7
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
COLOGNE
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.