Objective
The objective of DeZnIT is to develop and apply new methodology for the rational and accelerated design of novel drugs targeted against zinc-containing enzymes. These enzymes are key modulators of many serious human diseases including cancer, glaucoma, obesity, and rheumatoid arthritis. Despite some successes, many major technological challenges remain in the development of effective drug therapies against this enzyme family. The main challenges are:
1. Selectivity of drugs: The inhibition of a particular family member is required but structures are numerous and highly similar;
2. Drug developability: Potent inhibition of an enzyme is often achieved at the expense of other desirable properties;
3. Availability of accurate structural data for target enzymes: This is a real challenge for certain classes of Zn-enzymes;
4. Rational design of drugs: The involvement of a transition metal in the binding site presents special challenges in work on Zn containing enzymes.
DeZnIT will address these challenges by developing and integrating key technologies from pharmacogenomics, computer modelling, structural and molecular biology and chemistry, combined with drug discovery infrastructure and expertise. In particular, highly novel computational approaches taken from the field of computer science will be applied to drug design for the first time. The consortium members combine all the necessary competencies to achieve the goals and objectives of DeZnIT.
DeZnIT is highly focused on the identification of novel and more effective drug candidates, which will be further developed for serious human diseases. The other outcomes of DeZnIT are improved methods for computational drug design and other platform technologies such as, crystallography, molecular biology (including development of biomarkers) and chemical synthesis. Success of DeZnIT would lead to significantly reduced cost and timelines for drug discovery processes, with consequent health and economic impacts.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences clinical medicine ophthalmology glaucoma
- medical and health sciences clinical medicine rheumatology
- medical and health sciences basic medicine medicinal chemistry
- medical and health sciences health sciences nutrition obesity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-7
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
TAMPERE
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.