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Content archived on 2024-05-29

Novel post-genomic cell-based screens for drug targeting in membrane protein disorders

Objective

Elucidation of protein function is the next post-genomic challenge towards the understanding of biological processes in health and disease. Transcriptomics and proteomics approaches usually deliver long lists of "candidate" gene that are putatively associated with the respective disease. However, no functional information nor direct relationship with the pathology, is established. Strategies and tools are thus critically needed to distinguish genes and proteins with mere pathologic association from those primarily responsible for the basic cellular defect(s) in such pathologies. Membrane proteins, including receptors, channels, antibodies, transporters, etc. play major roles in cells and organisms as they are involved in important cellular mechanisms, such as communication, immunity, signalling and response to environmental stimuli.

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Call for proposal

FP6-2005-LIFESCIHEALTH-7
See other projects for this call

Coordinator

FUNDAC?O DA FACULDADE DE CIENCIAS DA UNIVERSIDADE DE LISBOA
EU contribution
No data
Total cost
No data

Participants (7)