Objective
With this project two major vaccine companies in Europe, IRBM (Merck) and Chiron, join their efforts with several European groups and one institution from Egypt to develop efficacious preventative and therapeutic Hepatitis C (HCV) vaccines. IRBM, in collaboration with CEINGE, has been working on a promising gene based HCV vaccine candidate using adenoviral vectors for delivery. This vaccine elicits potent CD4+ and CD8+ T cell responses and protects vaccinated chimpanzees from acute and chronic infection against challenge with a heterologous virus.
This vaccine candidate works by lowering viral replication, thus preventing chronic hepatitis. Chiron vaccine candidate consists in recombinant HCV glycoproteins, gpE1 and gpE2 associated to resemble to a pre-virion envelope structure. Protection against homologous and heterologous challenge, mediated by CD4+ T cell response and antibodies, was observed in experiments in chimpanzee using MF59 as adjuvant. This vaccine is already in phase 1 clinical trial.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- medical and health sciences health sciences infectious diseases RNA viruses hepatitis C
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NAPLES
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.