Objective
The heritability of coronary artery disease (CAD) and myocardial infarction (MI) has been unequivocally demonstrated. However, traditional technology, for example based on investigation of candidate genes, or linkage analysis, has failed to elucidate the genetic roots of the Number One killer in society. Cardiogenics will exploit the major advances in genomics to identify risk genes for CAD/MI. The investigators have established large collections of affected individuals with an exceptionally strong genetic signal and subjected these to high-density genome-wide association analyses. These and other components of a multi-step genome-wide based strategy will uncover strong candidate genes (SCG). The implications of SCGs will be tested by the integrated functional genomics programme. Specifically, we will relate variants of SCG to the transcriptomes of monocytes and coronary plaques as well as more complex human phenotypes. Moreover, SCG variants will be further characterised, by small interfering RNA technology in stem cells, at the protein level, and functionally investigated. Ultimately, our globally competitive, integrated programmes spanning from genome-wide mapping to cell biology will determine the physiological roles of genes and proteins implicated in CAD/MI genetics and thus lead to the identification of novel drugable targets.The likelihood that we will achieve our ambitious goals is greatly increased by the fact that we have brought together leading European academic groups, and received substantial financial and logistic support from major national initiatives (WTCCC in the UK and NGFN in Germany), large pan-European projects (MORGAM, BLOODOMICS, EUMORPHIA), and from Europe's premier genome centre, the WTSI. The seamless transfer of inventions to the small-and-medium-sized enterprises (EUROIMMUN and TRIUM) and the pharmaceutical sector will provide the basis of a return on the initial investment'.
Fields of science (EuroSciVoc)
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences health sciences nutrition
- natural sciences biological sciences genetics nucleotides
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-6
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
23538 LUEBECK
Germany
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Participants (18)
LEICESTER
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PARIS CEDEX 13
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CAMBRIDGE
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93042 REGENSBURG
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LONDON
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9892 AMSTERDAM
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MUENCHEN-NEUHERBERG
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MAINZ
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256 UPPSALA
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BELFAST
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LEEDS
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PAVIA
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LUBECK
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MUNICH
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MÜNCHEN
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93042 REGENSBURG
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MAINZ
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HELSINKI
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