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Content archived on 2024-05-29

Myeloma stem cell network: A translational programme identifying and targeting the early myeloma cell hierarchy

Objective

Multiple myeloma is an incurable disease of malignant plasma cells which accumulate in the bone marrow, for which novel and effective therapeutic approaches are vital. The European Myeloma Network (EMN) has recently been set up to investigate this disease, which may serve as a paradigm for incurable cancers. It is our belief that by defining the myeloma stem cell (MSC), this will accelerate our search for a cure for this debilitating disease.
Our proposals in pursuit of these aims are based on 3 integrated goals:
1. To establish a structural network with secure funding to underpin our co-ordinated research activities.
2. To formulate a scientific framework to define the MSC and its relationship to the tumor microenvironment.
3. To utilize insight from our scientific investigations to devise therapy, including immunotherapy.
For Goal 1, the EMN has set out to interweave European expertise, which is at the forefront of MM research as demonstrated by the high quality of research publications.
For Goal 2, the MSCNET has delineated key strengths and limitations in the current state of the art. We will set out an umbrella strategy to examine the key issues relating to the MM stem cell, introducing novel technologies to do so.
For Goal 3, it is clearly vital to define the stem or `feeder' cell in MM if the disease is to brought under long-term control or for curative treatment. This remains a pivotal question which will dictate future development of targeted therapy.'

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

FP6-2005-LIFESCIHEALTH-6
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

STREP - Specific Targeted Research Project

Coordinator

REGION NORDJYLLAND, AALBORG HOSPITAL
EU contribution
No data
Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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Participants (8)

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