Objective
Mounting evidence indicates that the acquired ability to resist apoptosis is a hallmark of most, and perhaps all types of cancer. As scientists learn more about how apoptosis is thwarted by cancer cells, they are also gaining a greater understanding of why many tumours are resistant to the apoptosis-inducing effects of radiation and chemotherapy. These insights will guide efforts to overcome treatment resistance and offer important clues about new drugs that target genes and protein products in the apoptosis pathways to encourage selective cell death. GROWTHSTOP is exploring how apoptosis is regulated and how it can be selectively triggered to induce suicide in cancer cells while sparing normal cells.
The GROWTHSTOP consortium applies a combination of high- resolution bio-imaging techniques, proteomics, cellular models, and in vivo tumour models towards:
(i) the understanding of the pathways that signal apoptosis in solid tumours,
(ii) their validation as viable targets for tumour suppression or regression in animal models in vivo, and
(iii) the discovery and validation of a novel, alternative class of inhibitors that target specific protein: protein interaction rather than, or in addition to, enzyme activity.
GROWTHSTOP's goal is establishing the manipulation of apoptotic pathways as a viable therapeutic strategy. Importantly, more than 30% of the applied budget will go to SME's that feed in expertise and capacity for chemical screening in order to ensure a rapid translation of novel screens and assays into an efficient search for specific drugs manipulating proapototic pathways.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomics
- medical and health sciencesclinical medicineoncology
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes
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Call for proposal
FP6-2005-LIFESCIHEALTH-6
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Funding Scheme
STREP - Specific Targeted Research ProjectCoordinator
INNSBRUCK
Austria