Objective NEUROscreen is an industry-lead project combining novel neural stem cell bioassays & post-genomic chemical genetics to discover potential drugs of relevance to neurological diseases, regenerative medicine & cancer. Small molecule inhibitors of the growth of clonal, human neural cancer stem cells have the prospect of being unique medicines targeting the elusive cancer stem cell. Chemical modulators augmenting the growth, survival or differentiation of normal brain cells have a prospect as preventative or regenerative medicines for neurodegenerative diseases i.e. Alzheimer's, stroke & Huntington's disease. The consortium will use quality controlled cell lines & genetic engineering technology to design unique bioassays with which the biological modulating capacity of small molecules will be evaluated in a multi-replicate manner. Advanced chemistry will be used for the intuitive design and synthesize of biologically active molecules. Screening will be achieved with cells made to a quality & quantity via innovative bioprocesses & handled with state of the art robotics. The project will enhance the utility of the cell lines by delimiting the in vitro neural potency of the stem cells; ongoing determination of differentiation capacity serves as a rigorous confirmation of utility. The project will focus on specific activities germane to a wider applied research field than its seeding project EuroStemCell. The consortium & project have been designed with a crucial alignment in mind to objectives of the Work Programme/Specific Programme for Integrating & strengthening the ERA i.e. gender & innovation aspects in research, international cooperation (3 countries & a new member state) and fostering ethical awareness in research involving human stem cells. More than 50% of partners represent European small- & medium-sized companies and this balance structures a consortium with greater potential than individual parts & will directly strengthen the ERA foundations.' Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverymedical and health sciencesmedical biotechnologygenetic engineeringmedical and health sciencesmedical biotechnologycells technologiesstem cellsmedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicineneurologystroke Programme(s) FP6-LIFESCIHEALTH - Life sciences, genomics and biotechnology for health: Thematic Priority 1 under the Focusing and Integrating Community Research programme 2002-2006. Topic(s) LSH-2005-1.2.5-3 - Use of cell lines to define new bioassays for the identification of therapeutic bio-molecules (especially orientated towards small and medium sized companies) Call for proposal FP6-2005-LIFESCIHEALTH-6 See other projects for this call Funding Scheme STREP - Specific Targeted Research Project Coordinator STEM CELL SCIENCES UK LTD EU contribution No data Address SALTIRE COURT, 20 CASTLE TERRACE EDINBURGH United Kingdom See on map Links Website Opens in new window Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all DIALECTICA SRL Italy EU contribution No data Address VIALE PASTEUR, 10 NERVIANO, MILAN See on map Links Website Opens in new window Total cost No data BIOREP SRL Italy EU contribution No data Address GALLERIA PASSARELLA N.2 MILAN See on map Links Website Opens in new window Total cost No data LIFE & BRAIN GMBH Germany EU contribution No data Address SIGMUND-FREUD-STR.25 BONN See on map Links Website Opens in new window Total cost No data THE CHANCELLOR, MASTER AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution No data Address THE OLD SCHOOLS, TRINITY LANE CAMBRIDGE See on map Links Website Opens in new window Total cost No data MEDICAL RESEARCH COUNCIL - NATIONAL INSTITUTE FOR MEDICAL RESEARCH United Kingdom EU contribution No data Address 20 PARK CRESCENT LONDON See on map Links Website Opens in new window Total cost No data SUMMIT PLC United Kingdom EU contribution No data Address 91 MILTON PARK, ABINGDON OXFORDSHIRE See on map Links Website Opens in new window Total cost No data RHEINISCHE FRIEDRICH WILHELMS UNIVERSITÄT BONN Germany EU contribution No data Address REGINA-PACIS-WEG 3 BONN See on map Links Website Opens in new window Total cost No data UNIVERSITA DEGLI STUDI DI MILANO Italy EU contribution No data Address VIA FESTA DEL PERDONO 7 MILAN See on map Links Website Opens in new window Total cost No data