Objective
Methicillin-resistant Staphylococcus aureus (MRSA), a virulent organism resistant to many drugs, is responsible for most nosocomial and community-acquired infections. It can cause life-threatening disease, and treatment options are limited. Effective and rapid diagnostics is a strategic key element in the campaign against the spread of MRSA, allowing infection surveillance and control measures as well as more efficient patient treatment, and overall decreased health cost.
The MagRSA project aims at the development of a new diagnostics platform that will provide a fast, simple and accurate identification of MRSA from clinical samples. The diagnostic protocol relies on a new and clinically validated procedure that consists in a direct one-step enrichment of MRSA present in either nasal, inguinal or wound swabs, followed by DNA extraction of immunocaptured bacteria and their identification by multiplex sequences amplification using quantitative PCR.
This protocol will be implemented with a simple 'hand-off' system based on:
(1) advanced microfluidic magnetic nanoparticles manipulation technology allowing efficient capture and extraction of target bacteria and nucleic acids, and
(2) novel strategies for the integration of full operations required for the entire nucleic acid analysis chain in a microfluidic platform.
Steps as sample preparation signal amplification by multiplex PCR and detection of multiple genes simultaneously will be integrated and automated in single fluidic chip. MagRSA project will bring together high-tech SMEs and advanced hospital/academic laboratories that are mutually independent leaders in their fields with complementary competencies. The ultimate objective is to reach a pre-clinical validation of the proposed diagnostic tool that not only addresses the unmet need in MRSA diagnostics but also opens new potential for a broad range of applications in the emerging molecular diagnostics market.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules nucleic acids
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences genetics DNA
- engineering and technology nanotechnology nano-materials
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-LIFESCIHEALTH-7
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
GENÈVE 4
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.