Brassinosteroids (BRs) are plant steroid hormones that regulate a variety of growth and developmental processes. Whether BRs are required and how their binding to particular receptors generates specific cell differentiation patterns in the context of a dev eloping organ is still unknown. The plant vascular system is composed of two tissue types, xylem and phloem, which originate from procambial stem cells that proliferate and differentiate to form vascular strands connecting all different parts of the plant.
The main objective of the project included in this proposal is to analyse the contribution of the BR-responsive BRI1/BRL1 and BRI1/BRL3 pathways in setting up the proliferation and/or differentiation of xylem and phloem tissues from pluripotent vascular s tem cells, using Arabidopsis thaliana as a model system. To reach this objective, I plan to use a multidisciplinary approach combining cell biology techniques, molecular genetics, plant physiology and genomics.
My final long-term goal is to bring together all the biological information on the role of BRs in vascular development using mathematical modelling. The proposed approach will provide further insights into the functional role of BRs in vascular development, their interplay with auxin and their potential application for crop improvement.
Field of science
- /natural sciences/biological sciences/genetics and heredity
- /natural sciences/biological sciences/molecular biology/molecular genetics
- /medical and health sciences/medical biotechnology/cells technologies/stem cells
- /natural sciences/biological sciences/cell biology
- /medical and health sciences/basic medicine/physiology
Call for proposal
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