Objective Our aim is to find new antibacterial molecules with novel mechanisms of action, by applying new and innovative approaches in organic and medicinal chemistry, such as diversity-oriented synthesis (DOS) and chemical genetics.The objectives are:-Development of diversity-oriented synthesis (DOS) using solid supported techniques to obtain collections of highly diverse and complex small molecules. The structure of the compounds will be designed in order to cover different spatial and electronic characteristics as well as different bonding and affinity possibilities.-Biological screening of the molecular libraries on cultures of human pathogenic bacteria and selection of the most active compounds to identify new modes of antibacterial action.This project addresses major challenges in both therapeutics and organic synthesis, such as bacterial resistance to existing drugs, catalytic asymmetric synthesis on solid phase and diversity-oriented synthesis and chemical genetics in Europe. It is a multidisciplinary project that involves a highly valuable education for the candidate in new scientific aspects related to her research field. Fields of science natural sciencesbiological sciencesgeneticsnatural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesbasic medicinemedicinal chemistrynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural scienceschemical sciencesorganic chemistryalcohols Keywords Diversity-oriented synthesis antibiotics asymmetric synthesis bacteria resistance chemical genetics drug screening solid-phase synthesis Programme(s) FP6-MOBILITY - Human resources and Mobility in the specific programme for research, technological development and demonstration "Structuring the European Research Area" under the Sixth Framework Programme 2002-2006 Topic(s) MOBILITY-2.1 - Marie Curie Intra-European Fellowships (EIF) Call for proposal FP6-2005-MOBILITY-5 See other projects for this call Funding Scheme EIF - Marie Curie actions-Intra-European Fellowships Coordinator THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE EU contribution No data Address The Old Schools, Trinity Lane CAMBRIDGE United Kingdom See on map Links Website Opens in new window Total cost No data
