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Synthesis and screening of new small molecules with antibacterial activity: Discovery of novel biological targets

Obiettivo

Our aim is to find new antibacterial molecules with novel mechanisms of action, by applying new and innovative approaches in organic and medicinal chemistry, such as diversity-oriented synthesis (DOS) and chemical genetics.

The objectives are:
-Development of diversity-oriented synthesis (DOS) using solid supported techniques to obtain collections of highly diverse and complex small molecules. The structure of the compounds will be designed in order to cover different spatial and electronic characteristics as well as different bonding and affinity possibilities.
-Biological screening of the molecular libraries on cultures of human pathogenic bacteria and selection of the most active compounds to identify new modes of antibacterial action.

This project addresses major challenges in both therapeutics and organic synthesis, such as bacterial resistance to existing drugs, catalytic asymmetric synthesis on solid phase and diversity-oriented synthesis and chemical genetics in Europe. It is a multidisciplinary project that involves a highly valuable education for the candidate in new scientific aspects related to her research field.

Campo scientifico (EuroSciVoc)

Parole chiave

Argomento(i)

Invito a presentare proposte

FP6-2005-MOBILITY-5
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Meccanismo di finanziamento

EIF - Marie Curie actions-Intra-European Fellowships

Coordinatore

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
Contributo UE
Nessun dato
Costo totale
Nessun dato