Objective
How epigenetic programming of promoter architecture compatible with cell fate decisions is established and maintained is not well understood. We will explore the concept that during the cell cycle or on gene silencing, the bHLH-LZ transcription factor USF is a critical determinant of promoter architecture by mediating the transient and targeted recruitment of chromatin organisers to genes targeted by the master regulator of melanocyte development the bHLH-LZ factor Mitf, and that USF thereby dictates the ability of Mitf to control melanocyte stem cell and melanoma proliferation/differentiation.
The specific aims are:
1. To determine promoter occupancy by USF and Mitf at key target genes during the cell cycle and on gene activation/repression.
2. To identify protein complexes through which USF mediates its effects on gene regulation.
3. To examine the role of USF in melanocyte stem cell proliferation and differentiation.
The results will reveal both general principles underlying gene regulation and the mechanisms of epigenetic re-programming necessary for lineage commitment. The proposal addresses important but poorly understood issues in cell fate determination with long term implications for stem cell therapy and USF-associated diseases such as hyperlipidemia and diabetes. Moreover the project extends the researcher and apos;s current interests and will provide high quality and apos;state-of-the-art and apos; technical and intellectual training that will equip him to fulfil his long term ambition for an independent research career in France. The project will also foster close collaboration and technology transfer between the host UK laboratory and the researcher and apos;s current group in France and enhance and extend a current informal and synergistic network of European laboratories working in this field.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- medical and health sciences clinical medicine oncology skin cancer melanoma
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences medical biotechnology cells technologies stem cells
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.