Objective
In the past decade, protein fragments acting in the disruption of interfaces have been evidenced, and are named the tilted or oblique peptides. Tilted peptides are short protein fragments able to destabilize lipid membranes. Tilted peptides can be function al protein motif involved in protein/membrane fusion processes and in other biological events related to the disruption of a hydrophilic/hydrophobic interface. In this program we aspire to obtain a fundamental understanding of the tilted peptides and their involvement in membrane fusion. In order to better understand the relationships between their lipid-destabilising activity and their properties, we will study the biophysical properties of four peptides (three tilted peptides and one non tilted peptide) with different techniques. With this mission we aim to uncover general principles that govern the structure and dynamics of tilted membrane peptides and to obtain a fundamental understanding of their architecture in relation to their function.
In particular, we will analyse the role of tilted peptide/lipid interactions in determining properties of proteins in membranes via an experimental approach using model membrane systems. We expect that our studies will provide new insight into the structure, function and dynamics of membrane proteins and how this is modulated by the lipid environment. The project will build on the knowledge and expertise that has been gained over the years in the laboratory in studying different aspects of protein-lipid interactions. This expertise ranges from advanced biophysical techniques to modern molecular biological approaches and from model membrane systems to intact biological membranes. For the synthesis of the peptides we will continue the longstanding collaboration with Prof. Liskamp. Most of the approaches we intend to us, such as wide-line solid state NMR, CD, DSC are available in-house. The mass spectrometry analysis will be done in collaboration with Prof. Heck.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences optics spectroscopy emission spectroscopy
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences chemical sciences organic chemistry amines
- natural sciences chemical sciences analytical chemistry mass spectrometry
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
UTRECHT
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.