Objective
Nutritional factors can have protective effects on mood alterations, cognitive dysfunction and impaired quality of life in vulnerable subjects such as the elderly. Most of these effects are usually attributed to direct effects of nutriments such as polyun-saturated fatty acids (PUFA) on cell membrane fluidity and function and other nutriments such as antioxidants on oxidative stress. We propose here to test the possibility that in addition to these effects, nutriments can act on neuroimmune interactions that ultimately modulate mood and cognition.
Depression is a common feature of medical illnesses characterized by chronic activation of innate immunity. Recent theories have proposed that pro-inflammatory cytokines play a role in the pathophysiology of depress ion and other behavioural alterations in the medically ill. More specifically, it has been shown that pro-inflammatory cytokines produced by cells of the innate immune system in response to pathogen-associated molecular patterns and to endogenous danger signals act on the central nervous system to trigger a brain cytokine system that play a role in the development of mood and cognitive alterations. Micronutriments, including omega-3 PUFA, are highly incorporated in the brain.
In addition, these factors have been shown to exert potent anti-inflammatory actions; a mechanism that could explain their effects on brain functions. The fundamental hypotheses to be tested in this proposal are that 1) mild to moderate chronic activation of the innate immune system, as reflected by increased inflammatory activity, is associated with mood and cognitive alterations, and 2) nutritional factors (e.g. diet rich in omega-3 PUFA) can modulate inflammatory status and therefore regulate cytokine-related mood and cognitive alterations. These hypotheses will be tested in the clinical situations of aging and obesity that are both characterized by increased inflammatory activity and a high prevalence of behavioural symptoms.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- medical and health sciences clinical medicine surgery
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine neurology dementia
- medical and health sciences health sciences nutrition obesity
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
PARIS CEDEX 07
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.