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Zawartość zarchiwizowana w dniu 2024-05-29

Nutrition and NeuroImmune Interactions: Effects on well-being and mental health

Cel

Nutritional factors can have protective effects on mood alterations, cognitive dysfunction and impaired quality of life in vulnerable subjects such as the elderly. Most of these effects are usually attributed to direct effects of nutriments such as polyun-saturated fatty acids (PUFA) on cell membrane fluidity and function and other nutriments such as antioxidants on oxidative stress. We propose here to test the possibility that in addition to these effects, nutriments can act on neuroimmune interactions that ultimately modulate mood and cognition.

Depression is a common feature of medical illnesses characterized by chronic activation of innate immunity. Recent theories have proposed that pro-inflammatory cytokines play a role in the pathophysiology of depress ion and other behavioural alterations in the medically ill. More specifically, it has been shown that pro-inflammatory cytokines produced by cells of the innate immune system in response to pathogen-associated molecular patterns and to endogenous danger signals act on the central nervous system to trigger a brain cytokine system that play a role in the development of mood and cognitive alterations. Micronutriments, including omega-3 PUFA, are highly incorporated in the brain.

In addition, these factors have been shown to exert potent anti-inflammatory actions; a mechanism that could explain their effects on brain functions. The fundamental hypotheses to be tested in this proposal are that 1) mild to moderate chronic activation of the innate immune system, as reflected by increased inflammatory activity, is associated with mood and cognitive alterations, and 2) nutritional factors (e.g. diet rich in omega-3 PUFA) can modulate inflammatory status and therefore regulate cytokine-related mood and cognitive alterations. These hypotheses will be tested in the clinical situations of aging and obesity that are both characterized by increased inflammatory activity and a high prevalence of behavioural symptoms.

Dziedzina nauki (EuroSciVoc)

Słowa kluczowe

Temat(-y)

Zaproszenie do składania wniosków

FP6-2004-MOBILITY-12
Zobacz inne projekty w ramach tego zaproszenia

System finansowania

IRG - Marie Curie actions-International re-integration grants

Koordynator

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE
Wkład UE
Brak danych
Koszt całkowity
Brak danych