Objective
Ribosome biogenesis is tightly linked to cell growth and the coordinated synthesis of the ribosome components involves the three transcriptional machineries.
The networks that control ribosome biogenesis are poorly understood. Data in yeast (C. Carles and M. Riva) suggest that Pol I transcription is the masterchief in the co-regulation of these three machineries for the coordinated synthesis of the ribosome components.
These results rise the following questions and objectives:
- Examine whether co-regulation of the three systems is conserved in mammalian cells.
- Given the important role of ribosomes in cellular growth, investigate whether increased Pol I activation could result in neoplastic transformation.
- Study the mechanisms of the co-regulation.
I will engineer mammalian cells expressing a constitutively active Pol I, based on the yeast approach. I will study the consequences of Pol I deregulation on Pol II and Pol III transcription, ribosome biogenesis and cellular growth that could result in oncogenic transformation.
Relevance to the FP6 objectives:
- Creation of ERA and networks: I will initiate a collaboration between the laboratories of N Hernandez (Switzerland) and C Carles (France);
- Increase the role of women in research: I am a woman;
- Solving major societal questions: our research might provide new clues for anti-cancer strategies.
Relevance to the Marie Curie Intra-European Fellowship objectives, training through research: I will move to the laboratory of N. Hernandez at the CIG (Lausanne, Switzerland) in a competitive institute and learn genome-wide analysis methods. I will benefit from the advice of both N. Hernandez, and C. Carles, with whom I will closely collaborate.
I will meet with renowned scientists both in Lausanne and Paris. I will have the opportunity to manage my own project and to develop it as a group leader in another institute after leaving the University of Lausanne.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LAUSANNE
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.