Objective
The insulin signalling pathway is highly conserved throughout animal evolution and it regulates multiple biological processes including metabolism, tissue growth and longevity.
Due to the high conservation of this pathway, genetic model organisms, such as the fruit fly Drosophila melanogaster, have been powerful in characterizing new regulators of insulin signalling and elucidating their biological functions.
This study is aimed to study the in vivo role of a potential modulator of the insulin-signalling pathway, TOR (target of rapamycin) complex 2, in Drosophila. The TOR kinase is present in two highly conserved complexes.
While the role of TOR complex 1 in the coordination of tissue growth and nutrient sensing is well established, the function of TOR complex 2 is poorly understood. In cell culture studies, TOR complex 2 has been shown to regulate actin cytoskeleton as well as to phosphorylate AKT/PKB, an effector kinase in insulin signalling pathway.
However, the in vivo role of TOR complex 2 in multicellular organisms has not been addressed. To this end, I have generated flies mutant for rictor, a gene essential for the function of TOR complex 2. Analysis of the rictor mutant flies should provide novel and significant insights into the physiological role of TOR complex 2.
As the function of the insulin signalling pathway is disturbed in diseases such as diabetes and cancer, the results of this study are likely to have ramifications to human health.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2005-MOBILITY-5
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
HEIDELBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.